Mechanical Ventilation Flashcards

1
Q

minute ventilation

A

RR x Vt = VE (RR x tidal volume - min vent)
Normal range: 4-8 L/min
Average ~ 5 L/min

pets 1-12 yo: 4-8 L/minn
infants 0-1 yo: 0.2-0.3 L/min/kg

Cardiac output range also 4-8 L/min

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2
Q

tidal volume (Vt)

A

6-8 mL/kg (start with 6)
normal volume of air inspired during each normal respiratory cycle
Should be enough to overcome dead space and supply alveoli with oxygen
Calculated based on ideal body weight

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3
Q

Tidal volumes for artificial ventilation

A

Normal: 6-8 mL/kg
Lung protective: 4-6 mL/kg
Recommendation: start with 6mL/kg

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4
Q

Respiratory rate for ventilation

A

Injury approach:
Use minute ventilation calculation to determine RR (100mL/kg/min).
ie: 100mL x 70kg = 7000mL = 7L
(minute ventilation requirement = 7L)

Vt - 70kg x 6mL/kg = 420mL

RR - 7000mL / 420mL = 16.6
(start lung injury pts at 16 RR)

Obstructive approach (asthma/copd)
Start with RR of 10-12 breaths/minn

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5
Q

Respiratory Frequency

A

The sum of RR set by ventilator PLUS any patient triggered breaths.

Assist control will give a full breath
SIMV allows pt to trigger breath of whatever size they’re able to do

NOT respiratory rate

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6
Q

anatomical deadspace

A

amount of gas delivered to pt that does NOT reach alveoli for gas exchange.

1mL x 1 pound ideal body weight

ie: 70kg = 150 lb = 150mL anatomical deadspace (Per breath)

tidal volume (420mL) minus deadspace (150) = 270mL

150mL per breath x16 breaths/min = 2.4L per min lost to dead space.

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7
Q

Alveolar minute ventilation

A

Minute ventilation minus deadspace

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8
Q

Mechanical deadspace

A

Loss of volume within the vent circuit
ie expansion of tubing due to pressure.

Adults: 2mL x PIP
ie 2mL x PIP 20 = 40mL

pets: 1mL x PIP
ie 1mL x PIP 20 = 20mL (significant percentage of total)

Pressure breaths: account for deadspace because ventilator delivers breath based on pressure, not volume.

Additional hardware like EtCO2 causes more volume loss (EtCO2 ~50ml/min)

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9
Q

Exhaled tidal volume (Vte)

A

Ate is an accurate measurement of the volume of air received by the patient if no leak is present.
Provides confirmation of volume delivered, while accounting for deadspace.
Will vary by breath based on lung compliance.

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10
Q

Inspiratory / expiratory phases (I:E ratio)

A

Expiration is longer and takes more energy.

I:E ratio - ratio between inspiratory and expiratory phases.

Adult starting point - 1:2
Red starting point: 1:3

Example:
10 breaths /min = 6 second breath cycle.
I:E of 1:2 = 2 sec for insp, 4 sec for expir.

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11
Q

Peak Inspiratory Pressure (PIP)

A

Measurement of pressure at upper airway, ETT, vent circuit, bronchial tree.
Maintain PIP at 35 cmH2O or less, generally
Asthma/COPD pts may need higher PIP

Causes of increased PIP:
Patient cough, secretion, needing suction, sedation status, small ETT, kinked ETT, kinked vent circuit.

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12
Q

Plateau Pressure

A

Measurement of pressure when inspiratory flow is zero.
Indicator of alveolar pressure.
Only applicable in a volume breath.
1/2 second inspiratory hold
Maintain plateau pressure less than 30

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13
Q

High plateau pressure

A

if greater than 30 cmHg, now what?
Lower Vt (ie from 6 mL/kg to 5 mL/kg)
Continue to reduce if necessary to a minimum of 4mL/kg

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14
Q

Causes of increased plateau pressure

A

Increased Vt
Decreased pulmonary compliance
Pulmonary edema
Pleural effusion
Peritoneal gas insufflation
tension pneumo
trendelenburg
ascites
Endotracheal intubation
abdominal packing.

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15
Q

Driving pressure

A

Keep at 15 or less for ARDS pts

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16
Q

What to monitor in volume controlled ventilation?

A

PIP, Pplat, and static compliance.

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17
Q

Sudden increase in PIP w/normal Pplat

A

Pt coughing against ventilator circuit

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18
Q

When using a pressure-control mode, what can you expect?

A

Ventilator triggers until a pre-set pressure limit is reached.

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19
Q

FIO2

A

fraction of inspired oxygen
Can be delivered from 21% (atmospheric) up to 100%
Goal is to maintain SpO2 > 93%
USe lowest FIO2 possible for SpO2 >93%

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20
Q

PEEP

A

Positive End-Expiratory Pressure: used to maintain alveolar recruitment

Improves oxygenation by reducing V/Q mismatch

Fastest way to improve oxygenation

Starting point: 5 cmH2O

PEEP increases intrathoracic pressure

When switching ventilators, clamp ETT at peak of inspiration to maintain PEEP during switch.

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21
Q

Volume vs pressure

A

Volume breath: similar to BVM
Defined inspiratory volume
Calculations based on ideal body weight
Starting volume 6-8 mL/kg
Lung protection: 4-6 mL/kg

Monitor effectiveness of volume breath with PIP (<35 cmH20 and Pplat <30cmH20).

Guaranteed minute ventilation is the same

Pressure breath:
Considered lung-protective
Compliance-based
Set inspiratory pressure
Adults: 20 cmH2)
Peds: 10 cmH2)
Monitor effectiveness with exhaled tidal volume Vte

In pressure ventilation, monitor volumes
In volume ventilation, monitor pressures

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22
Q

Assist control

A

AKA continuous mandatory ventilation (CMV)

Vent delivers a breath whether pt triggers it or not.

If pt triggers ventilator, volume is the same every time (preset by clinician)

As soon as ventilator detects negative pressure from pt triggering breath, ventilator delivers a pre-set volume.

Allows clinician not maintain control
Delivers present tidal volume and respiratory rate.
Guarantees minute ventilation Vte
Does not allow for patient respiratory drive

Pts are not allowed to take their own breath

Every time pt initiates a breath, the ventilator will deliver a full tidal volume.

Probably best for hospital setting.

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23
Q

SIMV

A

Synchronized intermittent mandatory ventilation

Vent delivers a breath when triggered by pt or by time.

When pt triggers a breath, vent delivers a pressure-supported breath.

Initially designed to help wean pts from mechanical ventilation therapy

delivers a preset tidal volume and respiratory rate.

Pt is allowed to trigger spontaneous breath between mandatory breaths.

Decreased chance of hyperventilation.

Possibly best for transport environment.

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24
Q

Pressure support

A

Only applies:
…while using SIMV
…During spontaneous pt breaths

Reduces deadspace
Increases pts ability to take spontaneous breath

Reduces pt breathing effort.

Only applied when pt takes own breath

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25
Q

Mechanical ventilation variables

A

Volume
Pressure
Rate
Flow
O2
Patient in charge
Ventilator in charge

26
Q

Pressure Trigger

A

Default adult setting of -2 or -3 cmH2O
peds: -1 cmH2O

Pt must exert negative pressure (inhale) I excess of trigger setting for vent to deliver prescribed volume.

Bias flow is the basis for flow triggering.

Flow sensor detects absence of flow to trigger a full breath.

Minimum pressure (trigger activation) is based on PEEP.

27
Q

PRVC (pressure regulated volume control)

A

AKA volume adaptive
…Pressure breath driven by compliance.

Learning/adaptive mode

Test breath - measures exhaled tidal volume.

Then adjusts inspiratory pressure.

Takes time for ventilator to learn ideal settings (can be a problem in a transport environment).

28
Q

Ppeak (PIP)

A

Airway resistance
Alveolar compliance
Should be < 35
Pts with more airway resistance will have higher PIPs
Elevated PIP is necessary in pts with high resistance in order to maintain ventilation.

29
Q

Airway resistance

A

PIP-Pplat / flow (L Per sec)

Common flow rates:
40 L/min = 0.67 LPS
50 L/min = 0.83 LPS
60 L/min = 1.0 LPS

ie 45-20/0.83 LPS = 30 cmH2O

30
Q

Dynamic Compliance

A

Compliance assessed with changing lung volumes during airflow.

airway resistance and alveolar compliance
Vt / (PIP-PEEP)

ie 400mL / (15-5) = dynamic compliance 40

Normal dynamic compliance ~ 40-100

31
Q

Static compliance

A

Compliance evaluated without airflow or volume changes

50-100 ml/cmH2O
lower than 40 = poor compliance

Alveolar compliance = Plateau pressure

Vt / (Pplat - PEEP)

ie 400 / (25-5) = static compliance 20

32
Q

PIP (Ppeak)

A

The highest pressure reached during inspiration, reflecting the effort required to inflate the lungs.
<35 generally
<30 for lung injury patients

33
Q

Inspiratory Resistance (Rinsp)

A

<8 generally
Higher in pts with obstruction (asthma/copd)

34
Q

Expiratory time constant (RCexp)

A

Indication of length of time it takes lung units to fill or empty

Goal is 95% of volume exhaled.

4 time constant levels:
1 x RCexp = 63%
2 x RCexp = 86.5%
3 x RCexp = 95%
4 x RCexp = 98%

35
Q

Mean Airway Pressure (Pmean)

A

<25

36
Q

Driving Pressure

A

Pplat - PEEP

37
Q

VLeak

A

<10
Bipap or CPAP
The lower the better.
Indicative of leak after the flow sensor.
Mask fit problem.

38
Q

Inspiratory Tidal Volume (VTI)

A

Volume delivered to pt as measured by flow sensor.
If there is a leak on the pt side of the vent circuit, the displayed VTI may appear larger than the displayed VTE.

39
Q

Airway Occlusion Pressure

A

Indication of respiratory drive / sedation status.

40
Q

beaking

A

Too much volume
reduce volume

41
Q

Rinsp

A

Resistance to inspiratory flow caused by the ETT and the pts airways during inspiration.

42
Q

High Flow Nasal Cannula (HFNC)

A

High O2 delivery
High flow delivery
Humidified air at 37 degrees C

Reduces deadspace
Reduction in rebreathing CO2
Improved alveolar oxygenation and ventilation
Reduction in work of breathing
Improved lung compliance
Improved mucous clearance
Decreased airway resistance
Decreased airway inflammation

When to consider HFNC tx
Delivered flow exceeds pts inspiratory demand.
Guaranteed 100% delivery FiO2
Meets pts flow and oxygen demands

43
Q

O2 Therapy delivery options

A

Low O2 therapy (NC, NRB, simple mask)
High Flow O2 therapy
CPAP
NiPPV - BiPAP
Mechanical Ventilation

44
Q

HFNC vs other forms of O2 therapy

A

Improves lung compliance and resistance by mechanism of an oxygen flow rate that meeds or exceeds the patients inspiratory flow rate.

This high flow also reduces dilution of gas (by room air) delivered through nasal cannula.

45
Q

HFNC energy reduction

A

humidifying and raising temp of inspired gases = reduced energy expenditure.
37C / 100% relative humidity (perfect)

46
Q

Sizing HFNC

A

Available in sizes 1-4
Should not occlude more than 50% of nare opening.

47
Q

HFNC settings

A

Flow: 20-35 L/min, increase by 5-10L/min
FiO2:
based on duration of transport
Start at 50-60% for bronchiolitis (RSV)/respiratory distress.
Target >93% SpO2
37C, 100% humidity.

<1 month <4kg. 5-8L/min
1-12 mo. 4-10kg. 8-20L/min
1-6 yrs. 1-20kg. 12-25L/min
6-12 yrs. 10-20kg 20-30L/min
12-18 yrs. >40kg. 25-50L/min

48
Q

ROX index

A

Used to evaluate O2 therapy effectiveness

(SpO2/FiO2) / respiratory rate

At 2, 6,12 hrs, if ROX > 4.88, tx is successful.
At 2 hrs, if ROX < 2.85 consider intubation
At 6 hrs, if ROX <3.47 consider intubation
At 12 hrs, if ROX <3.85 consider intubation

Faster RR causes ROX score to drop

49
Q

HFNC sizing

A

1-4 (4 is largest)
Size 1 has greatest flow of 30 L/min
Sizes 2-4 max flow 50 L/min

Sizing = <50% of the nare

50
Q

Non invasive ventilation (NIV/NIV-ST)

A

BiPAP vs CPAP
BiPAP adds iPAP

NIV-ST = non invasive spontaneous time

iPAP
…based on pressure support
…ability to deliver minute ventilation

EPAP
…PEEP
…oxygenation
…pt must be able to exhale over pressure

51
Q

Calculation of Oxygen Duration

A

[Current PSI - 200 (buffer) x FACTOR] / flow

Each size tank has its own factor.
M tank is 1.6.

ie: [(1800psi - 200) x 1.56] / L/min flow

This will give an estimate of how long you can run your oxygen at a given flow rate

52
Q

Indications for NIV

A

COPD
Asthma
CHF - Pulmonary edema
PNA
Covid-19
Undifferentiated hypoxia

53
Q

Additive ventilators

A

The sum of IPAP and EPAP should equate to Peak Inspiratory Pressure (PIP).

Additive ventilator example:
if IPIP is 12 and EPAP is 5, on the additive ventilator, Pressure support should be set to 7 and PEEP to 5.

54
Q

PEEPs

A

Positive end-expiratory pressure
A constant pressure applied at the end of exhalation, helping to keep alveoli open and improve oxygenation

55
Q

IPAP

A

The pressure delivered during inhalation on a ventilator, typically higher than EPAP

56
Q

EPAP

A

Expiratory positive airway pressure.
The pressure delivered during exhalation on a ventilator, often considered equivalent to PEEP.

57
Q

NIV example

A

If IPAP 12 and EPAP 6
…IPAP = 18, EPAP = 6, so total IPAP is 18 (12 + 6).
Total IPAP >20 cmH2O can cause the gastric sphincter to open and release volume into the stomach; resulting in nausea and potential vomiting.

58
Q

P-ramp

A

Controls the time it takes for ventilator to reach desired pressure.
0-200 ms
limited to 1/3 of TI time.

Adds comfort when set correctly.
If someone is air hungry, they’ll likely want a shorter p-ramp.

59
Q

Expiratory time sensitivity

A

AKA Flow Termination
Determines at what percentage of peak inspiratory flow a spontaneous breath is terminated.
Range 5-80%. Vent default is 25%
Higher % = shorter inspiratory phase and longer expiratory phase.

60
Q

NIV additional settings

A

Trigger (flow) 3-20 L/min
5 L/min is a great place to start

FiO2 - titrate to SO2 >94%

61
Q

NIV-ST advantages

A

Sets a minimum respiratory rate (10-12)
Allows pt drive, but insures minimum rate

Differences:
NOT pressure support.
…Pinsp drives mandatory + spont breaths.
Rate and TI define breath timing.
P-ramp 0-200 ms (limited to 1/3 TI time)