Endocrine Flashcards

1
Q

Endocrine system

A

Includes pituitary gland, hypothalamus, adrenal glands, thyroid gland (and others).
Regulate growth, metabolism, sexual development.

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2
Q

Serum osmolality

A

275-295 mOsm/kg
(about double normal Na level)

Helps maintain fluid balance.
Measure of solute in relation to available fluid or plasma.
If >295, pt is volume depleted (high = dry)
…body will attempt to retain fluid by releasing ADH.
If <275, pt os volume overloaded and body doesn’t release ADH

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3
Q

SIADH

A

Too much ADH is released.
Pt retains water.
Oliguria (decreased output)
…will have high specific gravity (>1.030)
Dilutional hyponnatremia
Serum osmolality <270
Edema is NOT present
Neuro sx caused by cerebral edema
Pulmonary edema and dyspnea

Causes:
carcinoma of the lung
…produces a substance like ADH
Head problems
…trauma, tumors, CVA, meningitis
Hypoxemia
Nephrogenic causes
…anesthetics, narcotics, Tylenol, anticonvulsants

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4
Q

SIADH treatment

A

Fluid restriction
Consider hypertonic saline
…1-2mL/kg/hr until asymptomatic
Raise serum sodium 0.5mEq/L per hour
Can raise Na faster if the drop was faster
Consider lasix 1mg/kg
Avoid hypotonic solutions
Don’t use D5W

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5
Q

Diabetes Insipidus

A

Opposite of SIADH - not enough ADH
Constant urination (polyuria)
Low urine specific gravity (clear)
Dehydration
Elevated serum Na
Elevated serum osmolality
urine hypo-osmolality

Causes:
head injury, infection, tumors, lithium, dilantin

Results in:
Hypovolemia, shock, electrolyte imbalances

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6
Q

Treatment of Diabetes Insipidus

A

Aggressive IV fluid replacement.
Raise sodium slowly
Consider vasopressin (synthetic ADH)
Monitor urine specific gravity and cardiac changes.

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7
Q

DKA

A

Not enough insulin, body breaks down fat
…Buildup of ketones
Leads to acidosis.
Characterized by hyperglycemia, dehydration, and acidosis.
Acidosis with elevated glucose is an indication of DKA rather than HHS

Symptoms:
Acidosis (elevated ketones)
Ketones can cause fruity breath
Kussmaul respirations (rapid, shallow to breath off CO2
Increased serum osmolality
Dilutional hyponatremia.
Potassium loss from inside cell to oudside cell (trying to offset hydrogen
…potassium may be elevated initially

Hypokalemia is most common cause of death

For every 100mg/dL glucose over 100, serum sodium decreases by 1.6 mEq/L

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8
Q

DKA treatment

A

Aggressive fluid: 100-150mL/kg
…1/2 in first 8-12 hrs and rest in 16-24hr
Switch to D5NS when glucose = 300

Insulin drives glucose, K, and H2O back into cells, so if they haven’t been hydrated they could go into circulatory collapse.

When managing DKA, focus on treating acidosis prior to administration of insulin.
…focus on improving acidosis, not glucose.

Prevent hypokalemia
Add 10-40 mEq/L/hr to fluids

Add insulin after hydrating and managing K
0.1 units/kg bolus. Same dose/hr drip

Don’t reduce glucose > 100mg/dL/hr
…glucose is a large molecule; water follows it easily which can cause fluid to third space back into the tissue, especially the brain…causing cerebral edema.

Bicarb will be low due to metabolic acidosis but not routinely given because when insulin is given, lactate and ketones will be metabolized into bicarb.

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9
Q

Corrected Sodium (DKA)

A

measured sodium + (serum glucose-100)0.016

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10
Q

Hyperosmolar Hyperglycemic State (HHS)

A

Similar to DKA but these pts still have some insulin…aren’t breaking down fatty acids
Acidosis NOT present
Blood sugar range 1000-2000
…Takes longer for sx to present themselves
Dehydration

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11
Q

HHS treatment

A

Aggressive fluid (1-2L in first 2 hrs)
Switch to 1/2NS once blood pressure and urine output stabilize.
Switch to D5NS when glucose = 300
Add insulin 0.1units/kg bolus, same dose/hr drip
Do not reduce glucose >100 mg/dL/hr

Prevent hypokalemia
…start K replacement at 5 or less because giving insulin will cause lower K.

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12
Q

Thyroid Storm

A

Life threatening exacerbation of HYPERthyroidism
Excess circulating thyroid hormone
Impacts many systems
O2 demand quickly exceeds supply
Anaerobic metabolism…increased lactate

Triad:
Hyperthermia - up to 104
Tachycardia
AMS
Diaphoresis, N/V/D
Decreased TSH, increased T3 and T4

Cardiovascular collapse, hypovolemia

Treatment:
Propranolol, esmolol (B-adrenergic blocker
Block new hormone production
…PTU and methimazole
Treat adrenal insufficiency w/glucocordicoids (dex or hydrocortisone

Supportive care:
Aggressive cooling
Acetaminophen (only) for fever
D5NS for dehydration and hypoglycemia
Benzos for agitation
May have crackles but not from overload

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13
Q

Myxedema Coma

A

Extreme manifestation of HYPOthyroidism

Compensatory response to hypothyroidism is overwhelmed by precipitating factors, leading to a loss of brain function.

Findings:
hypothermia, puffy face, edema, dry skin
AMS, bradycardia, hypotension

Free T4/T3 low. TSH high

90% cases occur during winter months.

Treatment:
IVF resuscitation, vasopressors if needed.
IV corticosteroids
IV thyroid hormone replacement

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14
Q

Cushing’s syndrome

A

prolonged exposure to glucocorticoids or pituitary tumor.

Weight gain, buffalo hump, moon face.

Treatment:
Surgical removal of tumor
adrenal steroid inhibitors
Gradual removal of glucocorticoids.

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15
Q

Adrenal Insufficiency

A

Occurs when the adrenal glands fail to supply the body’s demand for glucocorticoids; cortisol and aldosterone.

Cortisol:
helps regulate blood sugar
holds back immune response
released in response to stress

Aldosterone
Helps maintain BP and water/salt balance

Adrenal insufficiency findings:
Hypotension, not responsive to IVF/pressors
Hypoglycemia
Abdominal pain/tenderness
Fever
confusion/lethargy
Low bicarb, non anion gap metabolic acidosis

Treatment:
IVF = D5 NS (2-3L)
Administer steroids (hydrocortisone, dexamethasone, prednisone)
Vasopressors if not responsive to IVF

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16
Q

Sickle Cell Crisis

A

Autosomal recessive disorder most common in ppl with African ancestry

Sickle shaped RBCs

Increases risk of infection due to damaged cells clogging the spleen.

Symptoms: most commonly severe pain

Treatment:
pain management
Maybe PRBC transfusion

17
Q

Sepsis

A

Systemic inflammatory response to infection

18
Q

Clotting cascade

A
  1. Vasoconstriction
    Vessel walls constrict, causing reduced blood flow to injury
  2. Platelet plug formation
    Platelets aggregate to the injury site and stick together, forming a ‘plug.’
  3. Clot formation
    Fibrin proteins stick together in a mesh-like structure, forming a clot

Clot is then broken down after bleeding stops

19
Q

DIC (disseminated intravascular coagulopathy)

A

Not a specific disease - always secondary

Overstimulation of the clotting cascade, secondary to massive tissue damage.

Causes blood clots to form through body’s small blood vessels.

Clots can reduce or block blood flow leading to organ/tissue damage.

Excessive clotting uses up platelets and other clotting factors which can lead to significant bleeding.

True danger lies not in excessive bleeding but in formation of clots within small blood vessels - leading to tissue ischemia and organ failure.

Contributing factors: sepsis, surgery, trauma, cancer, pregnancy/childbirth

Treatment:
Treat underlying condition.
Heparin (inhibits conversion of prothrombin to thrombin)
Anti-thrombin 3
TXA -tranexamic acid if active bleeding only

20
Q

SIRS (systemic inflammatory response syndrome)

A

Sepsis screening criteria:

temp >38C or <36C
HR >90
RR >20 or PaCO2 <32 mmHg
WBC >12k or <4k

21
Q

Septic Shock

A

Sepsis with profound circulatory, cellular, and metabolic abnormalities.

Requires vasopressors to maintain MAP of 65 or greater.

Serum lactate >2 in absence of hypovolemia

22
Q

Sepsis pathophysiology

A

Immune system over-activated

Inflammatory cascade:
pro inflammatory cytokines and mediators
Capillary leakage –> profound vasodilation and hypotension

Neutrophils release nitric oxide which is a potent vasodilator

Inflammation - coagulation
Clot formation
Production of thrombin leads to fibrin clots –> potential to develop DIC

Cardiovascular insufficiency
multi-organ failure

23
Q

Sepsis presentation

A

Initially hyperdynamic (high cardiac output), but become hypodynamic as sepsis progresses

Ventricular dilation
Loss of sympathetic responsiveness
Hyperventilation with respiratory alkalosis

24
Q

Sepsis treatment

A

Rapid fluid resuscitation and early abx
30mL/kg IVF based on actual body weight

Fluids started within 1 hour and completed within 3 hrs of initial presentation

Large, rapid fluid boluses w/reassessment

abx should be started within 1 hr

Vasopressors if IVF no longer effective
…norepinephrine first line
Possibly epinephrine or vasopressin

If IVF and vasopressors are not sufficient within the first 6 hrs, consider dobutamine or PRBC transfusion

25
Q

In hypovolemic shock, anticipate this type of renal failure…

A

pre-renal failure.
Kidneys are not being perfused enough, so there is a failure ‘before’ the kidneys.