Lab Values Flashcards

1
Q

Electroneutrality

A

in aqueous solution, in any compartment, the sum of all the + ions must equal the sum of all negatively charged ions.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Basic metabolic panel (wishbone)

A

wishbone

cations anions kidney
Na+ | Cl- | BUN /
135-145 |95-105| 4.5-11 / GLU
————————————- 60-110
K+ | HCO3- | CR \
3.5-5 | 23-30 | 0.6-1.2 \

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

K+

A

3.5-5
dominant inntracellular cation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Na+

A

135-145 mEq/L
dominat extracellular cation
Constitutes 90% of cations in extracellular fluid
Responsible for determining osmotic pressure
Helps maintain acid-base balance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cl-

A

95-105
strong acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

HCO3-

A

normal serum bicarb 23-30
referenced as CO2
base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

BUN

A

4.5-11

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CR

A

0.6-1.2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Glucose

A

60-110

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

cations

A

Na+
Ca++
H+
Mg+
K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

anions

A

Cl-
HCO3-
CN- (cyanide)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fluid vs concentration

A

labs measure a ratio of volume % to solute.
labs measure extracellular concentration.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Hypovolemic Hyponatremia

A

Na+ < 135 mEq/L
low volume and low sodium
diuretics, burns, vomiting, diarrhea
Treatment: isotonic fluids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hypervolemic Hyponatremia

A

Na+ < 135 mEq/L
Volume overload
Kidneys cannot excrete water efficiently
CHF, kidney injury, SIADH
Treatment: sodium-fluid restriction, diuretic therapy.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Euvolemic Hyponatremia

A

Na+ < 135 mEq/L
Normal water content w/low Na+
SIADH (antidiuresis hormone). Pts hold on to water.
Normal BUN and Cr.
Urine specific gravity will be high.
Treatment: fluid restriction, lasix, hypertonic raise Na+ 0.5 mEq/L per hour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

hypovolemic hypernatremia

A

Na+ > 145 mEq/L
Sweating (free water loss), fever
Treatment: isotonic fluids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

hypervolemic hypernatremia

A

Na+ > 145 mEq/L
Sodium retention
Resuscitation w/NS
Cushing syndrome
Aldosterone
Urine Na+ >20
NaHCO3- administration
Treatment: diuresis, hypotonic solution (free water)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

K+

A

3.5-5 mEq/L
Major intracellular cation
regulated by kidneys
essential for cardiac, muscle, and CNS function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

hyperkalemia

A

> 5 mEq/L
adrenal insufficiency
kidney function
tissue damage (ie burn)
Excessive K+ intake
metabolic acidosis
Hemolysis

Sx: fatigue, paresthesia, paralysis, palp, Brady, new 2nd or 3rd degree blocks, wide complex tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

hypokalemia

A

<3.5 mEq/L
sx:
hypotension
ventricular arrhythmia
DKA
cardiac arrest
Brady or tachycardia
respiratory arrest
lethargy, decreased strength

t-wave flattening, inverted t-waves, prominent U-waves, ventricular arrhythmias, atrial arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Cl-

A

95-105 mEq/L
Major anion of extracellular fluid
passively moves with Na and water
necessary for K+ retention and CO2 transport
most common cause of high Cl = NS resuscitation (hyperchloremic metabolic acidosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Serum bicarb (CO2)

A

23-30 mEq/L
CO2 = serum bicarb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

BUN

A

4.5-11 mg/dL
indication of real health
urea is a waste product of the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Cr

A

0.6-1.4 mg/dL
indication of muscle breakdown
indicates kidney function by identifying glomerular filtration rate
indication of hypovolemia (elevated Cr)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
GLU
60-110 mg/dL primary source of energy glucose regulated by insulin from pancreas
26
beta-hydroxybutyrate (BHB)
0.4-0.5 mmol/L predominant ketone body at onset of DKA allows earlier identification of DKA
27
Mg++
1.5-2.5 mEq/L found 50% inn bone and/or 45% intracellular low Mg is usually seen with deficits in Ca and/or K
28
hypermagnesemia
>2.5 mEq/L usually cleared by kidneys; seen in renal failure. Loss of deep tendon reflexes
29
hypomagnesemia
<1.5 mEq/L associated with hypokalemia or hypocalcemia causes neuromuscular irritability and mood changes. Mg loss in ICU patients... ...Urine loss, GI loss, Meds (abx), nutrition, stress response
30
phosphorus (P+)
3-4.5 mEq/L provides mineral strength to bones strong relationships between P and Ca High P+ likely means low Ca level, vice versa Causes tetany, sz, hypotension
31
Calcium (Ca++)
8.8-10.2 mg/dL essential for blood coagulation, endocrine and neurological functions parathyroid, thyroid, and vit D influence Ca values kidney disease will cause reduction in Ca++ reciprocal relationship with P+ (high Ca = low P, vice versa. Pts w/kidney disease always have lower Ca
32
hypercalcemia
>10.2 mg/dL paresthesia, weakness pancreatitis arrhythmias, shortened QT hypotension confusion
33
hypocalcemia
<8.8mg/dL numbness in perioral area hypotension coarse, brittle hair seizures numbness in fingers and toes muscle cramps dysphagia Low Ca++ = elevated P+ and vice versa
34
***Chvostek's sign***
Indication of low Ca++ touching side of cheek draws cheek/lip up.
35
***Trousseau's sign***
indication of low Ca++ sign of muscular excitability inflated BP cuff causes flexion of hand towards forearm
36
Complete blood count (CBC)
WBC Hgb Hct Plt RBCs
37
RBC
M: 4.7-6.1 million/mcL F: 4.2-5.4 million/mcL Decreases can be due to iron deficiency, blood loss, bone marrow suppression Increases can be due to high altitude, compensation for hypoxia (ie sleep apnea), dehydration, medications
38
Hemoglobin (Hgb)
M: 14-18 g/dL F: 12-16 g/dL Oxygen carrying capacity of RBCs Carries CO2 back to the lungs as carboxyhemoglobin Transfusion <7g/dL 1 unit increases hgb by 1g/dL
39
Hematocrit (Hct)
M: 42-52% F: 37-47% Percent of volume made up of RBCs Normal range is 3x greater than Hgb 1 unit increases hct by about 3%
40
low Hct
M: <42% F: <37% Low in anemia, SIADH (not diuresing), overhydration (higher volume w/same RBCs)
41
high Hct
M: >52% F: >47% Higher concentration of RBCs due to less volume. Dehydration, polycythemia (more RTBC production...ie COPD)
42
indices
measure characteristics of erythrocyte (RBC). Used to dx anemia 1. mean corpuscular volume (MCV) 2. Mean corpuscular hemoglobin (MCH) 3. Red cell distribution width (RDW)
43
mean corpuscular volume (MCV)
80-95 fL measurement of average size/volume of RBC high MCV = larger than normal RBC (b12 or folate deficiency low MCV = iron deficiency
44
Mean corpuscular hemoglobin (MCH)
23-31 pg amount of Hgb per RBC average weight of Hgb in RBCs high MCH: liver disease, hypothyroid, etoh abuse low MCH: iron deficiency, lead poisoning, CKD
45
Red cell distribution width (RDW)
11-15% Measurement of variation in size of RBCs Most issues are caused by greater RBC width
46
Platelets
150-400 mcL formed in bone marrow essential for clotting
47
Thrombocythemia
>400/mcL (High platelet count) anemia polycythemia (high RBC in relation to volume) Inflammatory disorders
48
Thrombocytopenia
<150/mcL (low platelet count) DIC (clotting disorder - too much clotting) Heparin induced thrombocytopenia sepsis bone marrow failure, cancers certain viruses (hantavirus)
49
White blood cells (WBC)
4,500-11,000 cells/mcL Responds to an inflammatory process. Elevated in infections, inflammation, stress Decreased in cancer, bone marrow damage, HIV, hepatitis, malnutrition, dehydration. When abnormal, the differential count is utilized to measure which types of WBC is affected. Never Let Monkeys Eat Bananas Never - Neutrophils Let - Lymphocytes Monkeys - monocytes Eat - eosinophils Bananas - basophils
50
Neutrophils
45-75% (segs) specific to bacterial and fungal infections
51
Lymphocytes
18-45% specific to viral illnesses regulate T and B cells
52
Monocytes
1-10% clean-up (phagocytosis)
53
Eosinophils
0-7% allergic reaction, parasites
54
Basophils
0-2% inflammatory response marker
55
Coagulation studies
PT PTT INR Ammonia
56
INR
0.8-1.2 (international normalized ratio) Measurement of how long it takes blood to clot compared to a standard rate. Often used to monitor effects of blood thinners like Coumadin. Elevated INR = blood clots more slowly
57
PT
10-13 seconds Prothrombin time Measures the time it takes for plasma (liquid part of blood) to clot. Used in combination with INR, which standardizes the PT results, allowing for consistent interpretation.
58
PTT
25-35 seconds Partial prothrombin time Often specific to pts on heparin Tool in dx and monitoring clotting, bleeding disorders, or heparin therapy Normally drawn with abnormal bleeding, chest pain, liver disease, suspected PE
59
Serum Osmolality
275-295 mOsm/kg Amt of solute in serum part of blood Body regulates osmolality by withholding or secreting ADH More cellularly hydrated, the lower the # High: concentrated state (diabetes insipidus...lack of ADH...lots of urination) Low: diluted stater (SIADH - lots of ADH...holding onto volume/urine)
60
urine specific gravity
1.005-1.030 measurement of concentration of urine. ratio of urine density and water density low number = more diluted urine high umber = more concentrated urine
61
***high Urine specific gravity***
>1.030 concentrated urine state SIADH. ADH overstimulated, holding onto fluid (urine). Lots of fluid vs solute. Dehydration...causes include vom/diarrhea ***SIADH: low serum os but high specific grav***
62
***low urine specific gravity***
<1.005 Decreased USG is dilute - closer to water. diabetes insipidus Less release of ADH = lots of peeing. Urine is diluted but cells are dry so serum os is high. Specific gravity is low.
63
troponin
<0.04 ng/mL Protein that is essential for muscle contraction. Binding site for calcium Troponin levels start rising 3-4 hrs after myocardial injury. Peak around 12 hrs.
64
CK-MB
0-0.3ng/mL Creatine kinase - muscle brain Found in cardiac muscle and some skeletal muscle (can be elevated in both cardiac and skeletal muscle damage) Compare to total CK.
65
high CK-MB
>0.3 ng/mL if CK-MB to CK ratio is >2.5-3, likely indicates cardiac damage.
66
proBNP
<100pg/mL NT-proB-type natriuretic peptide Secreted by cardiomyocytes based on ventricular stretch. Used as a marker in CHF patients. <125 for 0-74 yrs old <450 for 75-99 yrs old
67
Beta-hydroxybutyrate (BHB)
0.4-0.5 mmol/L predominant ketone body at ONSET of DKA allows earlier identification of DKA
68
Magnesium (Mg++)
1.5-2.5 mEq/L Essential to bone health. Found 50% in bone and/or 45% intracellular Low Mg++ usually seen w/deficits in Ca and/or K.
69
Hypermagnesemia
>2.5 mEq/L Usually cleared in kidneys. High Mg usually seen in renal failure. Sx: Loss of Deep tendon reflexes.
70
Hypomagnesemia
<1.5 mEq/L Seen in 50% of ICU patientns Associated with low Ca and low K Causes neuromuscular irritability and mood changes. Mg loss in ICU patients... 1. urine loss 2. GI loss 3. Medications (abx) 4. Nutritionn 5. Stress response
71
Phosphorus
3-4.5 mEq/L Provides mineral strength to the bone Strong relationship between P+ and Ca++
72
Hyperphosphatemia
>4.5 mEq/L Acidotic states. High P+ = Low Ca, vice versa Sx: tetany, seizures, and/or hypotension
73
ADH
Antidiuretic hormone Secreted by posterior pituitary Release of ADH = reabsorption of water in kidneys.
74
Diabetes Insipidus
Less release of ADH... ...Kidneys don't reabsorb water Lots of urination (peeing out dilute urine) S/S of dehydration. Decreased: ...urine specific gravity ...urine osmolality ...urine sodium levels Increased: ...BLOOD (serum) osmolality ...BLOOD sodium levels
75
SIADH
...excess release of ADH... kidneys increase reabsorption of water S/S: small amts of concentrated urine fluid volume excess: crackles, JVD, weight gain, HTN, tachycardia Dilutional hyponatremia - confusion, sz. Increased: (concentrated urine) ...urine specific gravity ...urine osmolality ...urine sodium levels Decreased: (diluted blood) blood (serum) osmolality blood sodium levels