Measuring kidney function Flashcards
What is renal clearance?
Volume of plasma completely cleared of a substance by the kidneys per unit time
The higher the renal clearance = more plasma is cleared of the substance
Which substances can be used to measure renal clearance?
Any substance
Value obtained depends on how the substance is handled by the kidney
What is the maximum possible renal clearance?
Plasma flow 650 mL/min
What molecule is often used to measure GFR?
Inulin
How does the kidney handle inulin?
Freely filtered at the glomerulus
Not reabsorbed by the tubule
Not secreted by the tubule
What is GFR?
The rate at which the two kidneys form the filtrate
What is the average value of the GFR?
125 mL/min
Renal clearance of inulin = GFR of inulin TRUE or FALSE
TRUE
What is renal clearance of inulin?
Hypothetical volume of plasma completely cleared of inulin by the kidneys per unit time
If a substance is freely filtered, not reabsorbed or secreted renal clearance = GFR TRUE or FALSE
TRUE
In which cases will clearance of a solute be less than that of inulin?
Net reabsorption
Not feely filtered
In which cases will the clearane of a solute be more than that of inulin
Net secretion
In which cases if the clearance of a solute = 0
If solute is not filtered at all
Completely reabsorbed
Which equation do we use to calculate GFR?
Renal clearance equation
Substance must have GFR = renal clearance
Which two subtances are used clinically to measure GFR?
Inulin Serum creatinine