measuring channel activity 2

Question 1

what is a tail current

Answer 1

the current when a deolarising voltage is lost it is formed due to the channels still being open at the start of the hyperpolariation, howver the large drop in current is due to the change in volatage, then the decay is due to channels clsoing

Question 2

why do open single channels open and clsoe in in a random manner what are the two important general principles?

Answer 2

Markov statistics relays in dwell times which is random and distributed eponeatialy
the mean dwell time is 1 over sum of rates for leaving that state