inward rectifier Flashcards
are inward rectifier channels voltage gate?
no
what direction will k+ flow physiologically
outwarsn
why are inward retifilers called that
more readly flows k+ in during experimantal conditions
what is the mechism of action for inward rectification
ion block due to the channel habing a negativy chanrged pore which is blocked by spermaideine
why is the channel block so voltage dependent?
as the channel can accomodate 4 changes so it takes the movent if 4 changes across the memebrane before the spamidene cna block the pore
what class of molecuels block the inward rectifier
polyamines as they are charged at physiological pH
what is the most effective polyamien and why
spermine as it displaces upto 5 k+ ions to reach its deep blocking site
why is inward current not blocked K+
as K+ will repel the blocker
when will polyamines block the K+ channel?
when membrane potential is higher then EK
what does the inward retifier current contribute to the membrane current
maintains the resting membrane poteintial
