Measles and Morbilliviruses

Question 1

What are morbilliviruses?

Answer 1

• RNA viruses
• rash of the skin
• measles, rinderpest, PPR, CDV etc

Question 2

Origin of measles virus

Answer 2

• Al RAZI - differentiated smallpox and measles

- MeV and RPV share common ancestor

Question 3

Measles:

Answer 3

-incubation = 10-12 days
-red blotches appear 7-18days post exposure, Koplick’s spots
-fever, sneezing, coughing,
other infections

Question 4

Worldwide

Answer 4

-leading causes of death of young children despite presence of vaccine

Question 5

Vaccine

Answer 5

1st dose: 12months or older

2nd dose: 4 weeks after first dose, catches 5% of vaccinated who failed to respond to first dose

Question 6

Whats in the vaccine

Answer 6

Attenuvax - 1968
Mumpsvax - 1967
Meruvax - 1965

Question 7

How to make mumps vaccine

Answer 7

• swab patients throat
• inoculate nutrient broth and use to infect hen’s egg
• after several passages in eggs, remove embryo and culture cells
• passage virus in chick embryo cells 5 times
• test for virus attenuation and immunogenicity in humans

Question 8

Rinderpest

Answer 8

• cattle plague
• high mortality
• originated in Asia

Question 9

Canine Distemper Virus CDV

Answer 9

• first isolated by Henri Carré in 1905

- first vaccine developed 1938

Question 10

CDV

Answer 10

Transient fever 3-6 days post infection - ACUTE

-high potential for zoonotic spread

Question 11

Morbilliviruses

Answer 11

spread via two receptor molecules

Question 12

Novel rubulaviruses

Answer 12

Human parainfluenza virus (PIV)

-resp. tract illnesses