Measles

Question 1

What are the 6 clinical presentations of measles?

Answer 1

1. Fever
2. Conjunctivitis
3. Rhinorrhoea
4. Cough
5. Koplik’s spots around parotid duct
6. Maclopapular rash from face which spreads to entire body

Question 2

What are the 2 neurological complications that develop secondary to measles infection?

Answer 2

1. Encephalitis
2. Sub-acute sclerosing panencephalitis (SSPE) - “suppression-burst” EEG pattern

Question 3

What are the 5 complications secondary to measles infection?

Answer 3

1. Conjunctivitis
2. Otitis media
3. Bronchopneumonia
4. Giant cell pneumonia - immunocompromised or malnourished
5. Diarrhoea

Question 4

What is seen in cell culture in measles infection?

Answer 4

Multinucleated giant cells

Question 5

How is measles confirmed in the labratory?

Answer 5

1. Cell culture
2. PCR
3. Serology

Question 6

What group of individuals is the MMR vaccine contraindicated in?

Answer 6

1. Malnourished & immunocompromised children
2. Pregnant women

Question 7

Where does the measles virus colonise?

Answer 7

1. Viraemia
2. Respiratory epithelium
3. Skin