MCQ

Question 1

What is a consensus sequence?

Answer 1

Most commonly found sequence of DNA bases coding for similar structure or function in different organisms
eg Shine-Dalgarno, Kozak

Question 2

What is the 2nd messenger of PI3K/AKt signal transduction pathway?

Answer 2

PIP3

Question 3

Which is the associated GTPase of COPII associated vesicles?

Answer 3

SarI

Question 4

What is the enzymatic activity of EGF-R?

Answer 4

Tyrosine Kinase

Question 5

Mannose-6-phosphate marks proteins for what?

Answer 5

transport to lysosomes

Question 6

What is KDEL?

Answer 6

ER retrieval signal
A protein with a functional KDEL motif will be retrieved from the Golgi apparatus by retrograde transport to the ER lumen - by binding to KDEL receptor in COPI coated vesicles

Question 7

Which part of GPCR interacts with G protein?

Answer 7

3/4 and 5/6 cytosolic loops

Question 8

What is the function of VEGF in malignant growth?

Answer 8

neovascularisation

Question 9

How is EGFR affected by phosphorylation?

Answer 9

It can bind Grb-2

Question 10

What is the effect of promoter hypomethylation?

Answer 10

Activates genes

Question 11

What is the effect of histone methylation?

Answer 11

can activate or inactivate genes

Question 12

What is the effect of histone acetylation?

Answer 12

affects protein/DNA electrostatic interactions