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Pharmacology > MCPHS PA Pharmacology Thyroid Drug Info Exam 3 > Flashcards

MCPHS PA Pharmacology Thyroid Drug Info Exam 3 Flashcards

1
Q

What are the Specific Uses of Methimazole?

Hyperthyroid drugs (Thioamides)

A

Hyperthyroidism

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2
Q

What are the Actions of Methimazole?

Hyperthyroid drugs (Thioamides)

A

Inhibt Iodine incorporation into Thyroglobulin

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3
Q

What are the ADRs of Methimazole?

Hyperthyroid drugs (Thioamides)

A

Hepatotoxic (less risk than PTU)

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4
Q

What are the Facts you need to know about Methimazole?

Hyperthyroid drugs (Thioamides)

A

Drug of choice

Faster onset

Daily Dosing

Preferred post 1rst Trimester

Safe in Lactation

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5
Q

What are the Specific Uses of Propylthiouracil (PTU)?

Hyperthyroid drugs (Thioamides)

A

Hyperthyroidism

Thyroid Storm

Intolerance of methimazole

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6
Q

What are the Actions of Propylthiouracil (PTU)?

Hyperthyroid drugs (Thioamides)

A

Inhibit Iodine incorporation into Thyroglobulin

Blocks Peripheral conversion of T4 to T3

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7
Q

What are the ADRs of Propylthiouracil (PTU)?

Hyperthyroid drugs (Thioamides)

A

Agranulocytosis

Hepatotoxic

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8
Q

What are the Facts you need to know about Propylthiouracil (PTU)?

Hyperthyroid drugs (Thioamides)

A

Preferred in the 1rst Trimester

Safe in Lactation (drug of choice)

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9
Q

What are the Specific Uses of Sodium Iodide (I-131)?

Hyperthyroid drugs (Radioactive Iodide)

A

Measure Thyroid Function

Thyroid Cancer

(Thyroid Ablasion)

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10
Q

What are the Actions of Sodium Iodide (I-131)?

Hyperthyroid drugs (Radioactive Iodide)

A

Mimics Iodide

Gets taken up by thyroglobulin

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11
Q

What are the ADR’s of Sodium Iodide (I-131)?

Hyperthyroid drugs (Radioactive Iodide)

A

Permanant Hypothyroidism

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12
Q

What are the Facts do you need to know about Sodium Iodide (I-131)?

Hyperthyroid drugs (Radioactive Iodide)

A

Takes 4-8 Wks for Symptomatic Relief (w/ablasion)

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13
Q

What are the Specific Uses of Lugols solution and SSKI?

Hyperthyroid drugs (Potassium Iodide)

A

Thyroid Storm

Pre-op thyroidectomy

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14
Q

What are the Actions of Lugols solution and SSKI?

Hyperthyroid drugs (Potassium Iodide)

A

Saturate Thyroglobin w/ Iodine so it stops putting out T3/T4

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15
Q

What are the Facts you need to know about Lugols solution and SSKI?

Hyperthyroid drugs (Potassium Iodide)

A

Will cause an initial spike in T3/T4

Must give with Thiamide to prevent fatal hyperthyroidism

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16
Q

What is the Specific Use of Levothyroxine?

Hypothyroid drugs

A

Hypothyroidism

17
Q

What are the Actions of Levothyroxine?

Hypothyroid drugs

A

It is Synthetic T4

18
Q

What are the ADRs of Levothyroxine?

Hypothyroid drugs

A

nausea/vomiting/diarrhea
change in appetite & weight
sweating
headache
insomnia
reduction in bone mineral density (rare)

19
Q

If you Dose Levothyroxine to high what ADRs might you see?

Hypothyroid Drugs

A

Tachycardia / Angina

-Start with low dose in Cardiac compromise

20
Q

What are the Facts you need to know about Levothyroxine?

Hypothyroid drugs

A

Take on empty stomach with full glass of water

Seperate Antacids / iron by 4 hrs

Brand/generic bioequivalence issues,

Safe & preferred in pregnancy/lactation

-Assess TSH every 6 weeks while Preggers

21
Q

What is the Specific Use of Liothyronine?

Hypothyroid drugs

A

Diagnostic tool in T3 Supression test

22
Q

What are the ADRs of Liothyronine?

Hypothyroid drugs

A

Arrythmia

Tachycardia

Cardiopulmonary Arrest

Hypotension

MI

23
Q

What needs to be monitored while taking Liothyronine?

Hypothyroid Drugs

A

S/S

TSH

Free T4

BP

HR

Renal

24
Q

What are the Facts you need to know about Liothyronine?

Hypothyroid drugs

A

Rarely Used in Primary care

Dosing Monitoring involves Endocrinologist

25
Q

What is the specific use of Liotrix?

Hypothyroid drugs

A

Hypothyroidism

26
Q

What is the MOA of Liotrix?

Hypothyroid drugs

A

Combination of T4 and T3 (4:1 ratio)

27
Q

What needs to be monitored while taking Liotrix?

Hypothyroid Drugs

A

Monitor S/S

TSH

Free T4

BP

HR

Renal

28
Q

What are the facts you need to know about Liotrix?

Hypothyroid Drugs

A

It’s expensive

No conclusive benefit over T4 alone

Complex dosing

Not recommened for use.

29
Q

What are the specific uses of Desiccated Thyroids?

Hypothyroid Drugs

A

Hypothyroidism

30
Q

What are are Desiccated Thyroids?

Hypothyroid Drugs

A

“Natural” thyroid hormone derived from desiccated hog and beef thyroid.

31
Q

What must be monitored on Desiccated Thyroids?

Hypothyroid Drugs

A

S/S

TSH

Free T4

Hypersensitivity

32
Q

What are the facts you need to know about Desiccated Thyroids?

Hypothyroid Drugs

A

They are unstable

There are allergy issues

Bioequivalence vary with brand

No longer recommended for use

33
Q

What are the DDIs of Thyroid Hormones should we be aware of?

A

Antacids

Calcium

Al

Mg

34
Q

What needs to be monitored on Levothyroxine?

A

TSH (Always)

Free T4 (Sometimes or as Reflex)

Free T3 (Uncommon unless called fro by TSH/T4)

Hypothyroid Signs / Symptoms (S/S) may require Dose up

Hyperthyroid S/S may require Dose down

35
Q

What can leaving Hypothyroidism untreated in pregnancy lead to?

A

Increased risk of Maternal HTN

Abnormal Fetal Brain Development

Spontaneous Abortion

Low Birth Weight

Fetal Death

Pharmacology (14 decks)

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