MCPHS PA Pharmacology GH Drug Info Exam 3

Question 1

What are the Specific Uses of Pro-GH Recombinant GH and GHRH?

Answer 1

Replacement therapy (short Children, GH deff.)

Muscle wasting in HIV PT

Short Bowel Syndrome

w/TPN (nutritional support)

Question 2

What is the Specific use of Pro-GH recombinant IGF-1?

Answer 2

Severe GH resistance

IGF-1 Deff for long term treatment of Growth Failure

Question 3

What are the actions of Pro-GH drugs?

Answer 3

Increased Gluconeogenesis

Stimulate Bone Growth

Increased Lipolysis

Increased Muscle Mass

Stimulate Organ Growth (Except brain)

Decrease Body Fat

Question 4

What ADRs do Pro-GH drugs have?

Answer 4

Arthralgia

Musculoskeletal Pain

Metabolic Complications

Peripheral Edema

Injection Site pain

Flu-Like Symptoms

Hematologic Effects

Hypoglycemia (Mecasermin)

Question 5

What are the specific uses of Anti-GH drugs?

Answer 5

Pituitary Tumor

Excess GH

Gigantism

Acromegaly

HTN

Glucose Intolerance

Aleep Apnea

Question 6

What are the actions of Somatostatin analog Anti-GH drugs?

Answer 6

Inhibits GHRH release

Question 7

What are the actions of Pegvisomant (GH antagonist Anti-GH drugs)?

Answer 7

Blocks GH binding

Question 8

What are the ADRs of Pegvisomant (GH antagonist Anti-GH drugs)?

Answer 8

Chest Pain

Peripheral Edema

Injection Site reaction

Nausea

Flu-Like Syndrome

Elevated Liver Enzymes

Potential Antibody formation

GH deficient State

Increased Morbidity due to CV disease and Upper Airway obstruction.

Question 9

What are the ADRs of Somatostatin analogs?

Answer 9

Nausea/Vomiting

Flatulence

Abdominal cramps

Fatty Diarrhea

Injection site pain

Neurologic complications

Hyperglycemia (rare)

Increased Morbidity due to CV disease & upper airway obstruction

Question 10

Are there any special facts regarding Somatostatin Anti-GH drugs?

Answer 10

Lanreotide

More selective, but more expensive.

Octreotide

More Commonly used