MCPHS PA Pharmacology Steroid Drug Info Exam 3

Question 1

What are the specific uses of Glucocorticoid receptor agonists?

Answer 1

Acute / Chronic inflammation

(Asthma / COPD, Arthritis, Gout, MS, Cerebreal Edema, ETC)

Immunosuppression

Replacement therapy

Hematologic disorders

Question 2

What are the Actions of Glucocorticoid receptor agonists?

Answer 2

Inhibits Phospholipid Breakdown into arachidonic Acid

(inhibits inflammation / pain)

Immunosuppression

Question 3

What are the ADRs of Glucocorticoid receptor agonists?

Answer 3

Hyperglycemia Increased Lipolysis

Osteoporosis (if used long term) Weakness

Thinning of Skin Decreased Muscle Mass

Peptic Ulcer disease Growth retardation in Children

Immunosuppression Insomnia

Decreased Memory Psychosis

Cataracts (esp in children) HTN

Increase in intraocular Pressure (Glaucoma) HPA axis suppression

Question 4

What is the Specific Use of Mifepristone (Glucocorticoid Receptor Antagonist)?

Answer 4

Cushing Syndrome

Question 5

What is the Action of Mifepristone (Glucocorticoid Receptor Antagonist)?

Answer 5

Inhibits Glucocorticoid Receptor Activation

Question 6

What is the Specific Use of Fludrocortisone (Mineralocorticoid Receptor Agonist)?

(Aldosterone Analog)

Answer 6

Addison’s Disease (Adrenal Insufficiency)

Question 7

What is the Action of Fludrocortisone (Mineralocorticoid Receptor Agonist)?

(Aldosterone Analog)

Answer 7

Na/H2O retention

K efflux

Question 8

What are the ADRs of Fludrocortisone (Mineralocorticoid Receptor Agonist)?

(Aldosterone Analog)

Answer 8

HTN

Hypokalemia

Question 9

What are the Specific uses of Aldosterone Antagonists?

Answer 9

CHF

HTN

MI

Hyperaldosteronism

Question 10

What are the Actions of Aldosterone Antagonists?

Answer 10

NA/H2O Excretion

K influx

Question 11

What are the ADRs of Aldosterone Antagonists?

Answer 11

Hyperkalemia

Gynecomastia

Impotence

Question 12

What is the Specific use of Ovine Coricorelin (CRF) and Cosyntropin (Synthetic ACTH)?

Answer 12

Diagnosis of Adrenal insufficiency

Question 13

What are the Actions of Ovine Coricorelin (CRF)?

Answer 13

Increase in ACTH

Increase in Cortisol

Increase in Aldosterone

Question 14

What are the Actions of Cosyntropin (Synthetic ACTH)?

Answer 14

Increase in Cortisol

Increase in Aldosterone

Question 15

Are there any special facts about Ovine Coricorelin (CRF)?

Answer 15

Must monitor plasma levels.