MCPHS PA Pharmacology Benzo and Z drugs Exam 1

Question 1

What are the GABA A subtypes?

Answer 1

a 1-6

b 1-3

d

e

g 1-3

q

p

p 1-3 (GABA C)

Question 2

What are the GABA B subtypes?

Answer 2

1

2

Question 3

GABA receptor subtypes and effects

Answer 3

GABA A

a1 - (Z drug Target) Sedative / Hypnotic, reinforcing

a2 and 3 - Anxiolytic, anticonvulsant (a2)

a5 - Leaning and memory (Psuedoalzhiemers with extended use)

b3 - Respiratory Drive, hypnotic

GABA B

Muscle relaxant

Question 4

Z drugs

Answer 4

GABA A a1 subunit

Zolpidem

Zaleplon

Eszoplicone (Least Specific)

Question 5

Benzodiazepines (BZD)

Answer 5

Triazolam

Clonazepam

Alprazolam

Lorazepam

Diazepam

Oxazepam

Chlordiazepoxide

The Clear And Least Desirable Option, Chlordiazepoxide