MCBG 10 - collagen Flashcards
Name the two ways proteins are delivered to the plasma membrane for export?
regulated
constitutive pathway
Whats the most abundant protein in the body?
Collagen. 25-35% whole protein content
Whats the basic unit of collagen?
Tropocollagen
What is the structure of a collagen fibre?
3 triple helix structure
Why are glycine’s found in collagen?
It is the only amino acid with a small enough side chain in the middle of the helix
How often is glycine found in a collagen molecules?
Every third Amino Acid
What bond stabilised collagen?
H bonds
Where is type one collagen found?
(2 alpha-1 chains and 1 alpha-2)
Skin, tendons, ligaments, bone. (90% of collagen)
Where is type 2 collagen found?
Cartilage, Intervertebral discs
Where is type 3 collagen found?
reticulate (component of reticular fibres)
Where is Type IV found?
forms basal lamina, the epithelium-secreted layer of the basement membrane.
Where is Type V found?
cell surfaces, hair and placenta
