MBB 446 Learning 2 Learning Objectives

Question 1

Define all major hallmarks of cancer

Answer 1

N/A

Question 2

Identify and explain hallmarks of cancer using specific examples (research abstracts)

Answer 2

N/A

Question 3

About ____ Canadians will develop cancer in their lifetimes and ____ will die of the disease

Answer 3

• 1 in 2

- 1 in 4

Question 4

Define cancer

Answer 4

a group of diseases characterized by the uncontrolled growth and spread of abnormal cells

Question 5

How many types of cancer are there?

Answer 5

A group of diseases There are more than 200 different types of cancer. Cancer can develop from almost any type of cell in the body

Question 6

As normal cells evolve progressively to a _____ state, they acquire these hallmark capabilities.

Answer 6

neoplastic

Question 7

Another word for hallmark?

Answer 7

Phenotype

Question 8

What are the original 6 core acquired hallmarks of cancer?

Answer 8

1. Sustaining proliferative signaling
2. Evading growth suppressors
3. Activating invasion and metastasis
4. Enabling replicative immortality
5. Inducing angiogensis
6. Resisting cell death

Question 9

What 4 things does Proliferation of normal cells require?

Answer 9

• Requires growth signals
• DNA checkpoints
• Activating apoptosis (suicide)
• Reproductive quota

Question 10

Proliferation of normal cells requires growth signals. Which hallmark does this relate to?

Answer 10

Hallmark 1: Sustaining proliferative signaling

Question 11

Describe Hallmark 1: Sustaining proliferative signaling in normal vs. tumor cells.

Answer 11

Normal cells: require growth signals (GS) before they start dividing. These signals are transmitted into the cell by transmembrane receptors that bind distinctive classes of signaling molecules.

Tumor cells:
generate their own growth signals, thereby reducing their dependence on stimulation from their normal tissue microenvironment