L17 Mar 15 Flashcards
1
Q
• Role of epigenetic deregulation in transformation
A
NA
2
Q
Can aberrant epigenetic signatures be reversed therapeutically
A
NA
3
Q
Role of DNA methylation
A
DNA methylation regulates gene expression and provides a possible mechanism for step-wise differentiation from a totipotent cell
4
Q
Describe mammallian DNA methylation
A
CpGs are unevenly distributed in mammalian genomes
• Majority of CpGs methylated – decrease correlated with
differentiation in specific cellular contexts
• Transcribed gene bodies are methylated and active enhancers are
unmethylated
• 97% of promoter CpG Islands (CGI) are unmethylated and methylated
CGIs are repressed
5
Q
Slide 20
A
NA
6
Q
Slide 21
A
NA
7
Q
Slide 22
A
NA
8
Q
Slide 23
A
NA
