Mayo Neuro Board Review

Question 1

Neurochemical considerations in schizophrenia

Answer 1

excess of dopamine linked to psychotic symptoms

Question 2

Types of Dopamine Receptors

Answer 2

D1 cerebral cortex and basal ganglia
D2 striatum
D3 and D4 high concentration in the limbic system
D5 located in thalamus hippocampus and hypothalamus

Question 3

First line treatments for Schizophrenia

atypicals

Answer 3

risperidone
olanzapine
quetiapine
ziprasidone
aripiprasole

Question 4

second line schizophrenia tx

Answer 4

clozapine

needs monitoring agranulocytosis

Question 5

Typicals (may worsen neurocognitive functioning)

Answer 5

chlorpromazine
thioridazine
perphenazine
trifluoperazine
thiothixene
haloperidol
fluphenazine

Question 6

Associated Neuorlogic findings in Schizophrenia

Answer 6

ventricular enlargement
frontal lobe abnormality
decreased volume of basal ganglia, limbic areas, hippocampus, thalamus, temporal regions, parahippocampal gyrus

Hypofrontality: frontal lobe dysfunction

Increased D2 receptor density in striatum and nucleus accumbens
Abnormal saccadic eye movements
primtive reflexes