May Flashcards
Serum
Plasma minus clotting proteins
Hb + CO2
Carbaminohemoglobin
Hb + CO
Carboxyhemoglobin
Hypertonic solution
Crenation
RBC count
5million/ul
WBC count
4000-10000/ul
Hypotonic solution
Ghosting/lysis
Neutrophils granules
Hydrolases, myeloperoxidase, cathepsin g, collagenase, and elastase
Specific-Alk phos, lysozyme, collagenase
Also produce leukotrienes
Eosinophils granules
Specific- aryl sulfatase, histaminase, major basic protein and eosinophil cationic protein
Basophil granules
Specific- histamine, leukotrienes, SRS, heparin, eosinophil chemotactic factor, neutrophil chemotactic factor
Hemopoietic phases
Mesoblastic- 0-3 months
Hepatic- 1-10 months
Splenic- 2.5-6 months
Myeloid- 4 months on
CFU-S
GEMM Granulocytes Erythrocytes monocytes megakaryocytes
CFU-L
Lymphocytes
RBC development stages
Proerythroblast—Basophilic erythroblast—Polychromatophilic erythroblast—Orthochromatophilic erythroblast—-Reticulocyte—–RBC
Proerythroblast
1-2 nucleoli, basophilic, undergoes mitosis to make more
Basophilic erythroblast
More ribosomes with no nucleoli
Polychromatophilic erythroblast
Last stage of mitosis, obvious nuclear/cytoplasm nuclear changes
Granulocytopoiesis stages
Myeloblast—promyelocyte—myelocyte—-metamyelocyte—band—-mature
Myeloblast
Unable to tell between lineages, can undergo mitosis
Myelocyte
Where you can tell a difference between the lineages and is the last stage to undergo mitosis
Neutrophil kinetics
Medullary formation- Any that are developing
Medullary reserve- Ready to enter blood pool
Circulating pool
Marginal pool-Inner vessel walls
Metameylocyte
From here on, identify based on nuclear morphology
Primary nodule
Only present before birth
Secondary nodule
Germinal center present
Spleen artery division
Splenic—trabecular—central (white pulp is adventitia)—pulp (no adventitia, has tunica media)—sheathed (single layer ET)—terminal capillaries—splenic sinus—venules—splenic veins
Blood thymus barrier
Capillary wall—perivascular space (macrophages here—epithelial reticular layer with tight jx
