Mature Lymphoid Neoplasm

Question 1

What is the most common leukemia in adults in Western countries?
a) AML
b) ALL
c) CLL
d) CML

Answer 1

Answer: c) CLL

Question 2

What is the median age of diagnosis for CLL?
a) 50
b) 60
c) 72
d) 80

Answer 2

Answer: c) 72

Question 3

What is a characteristic morphological finding in CLL?
a) Reed-Sternberg cells
b) Smudge cells
c) Blast cells
d) Starry sky pattern

Answer 3

Answer: b) Smudge cells

Question 4

Which B-cell markers are expressed in CLL?
a) CD3, CD7
b) CD19, CD20, CD23
c) CD34, CD117
d) CD15, CD30

Answer 4

Answer: b) CD19, CD20, CD23

Question 5

What is the worst prognostic indicator in CLL?
a) Del(13q)
b) Del(17p) and TP53 mutation
c) CD5 expression
d) Presence of smudge cells

Answer 5

B

Question 6

What type of cells accumulate in CLL?

A) T-cells
B) B-cells
C) Plasma cells
D) Natural Killer cells

Answer 6

B

Question 7

What percentage of lymphocytes appear small and mature in CLL?

A) 50%
B) 65%
C) 85%
D) 95%

Answer 7

C

Question 8

What is the worst prognostic indicator for CLL?

A) Trisomy 12
B) Del(13q)
C) Del(17p) and TP53 mutation
D) CD20 expression

Answer 8

C

Question 9

Which of the following is NOT a typical marker for CLL?

A) CD19
B) CD20
C) CD23
D) CD56

Answer 9

Answer: D) CD56

Question 10

What is the standard approach for asymptomatic CLL patients?

A) Chemotherapy
B) Immediate stem cell transplant
C) Watch and wait
D) Total body irradiation

Answer 10

C

Question 11

Which of the following is a BTK inhibitor used in CLL treatment?
A) Venetoclax
B) Ibrutinib
C) Idelalisib
D) Alemtuzumab

Answer 11

B

Question 12

Which leukemia subtype is characterized by prolymphocytes in peripheral blood?
A) Chronic Lymphocytic Leukemia
B) Prolymphocytic Leukemia (PLL)
C) Hairy Cell Leukemia
D) Large Granular Lymphocytic Leukemia

Answer 12

B

Question 13

What is the primary site of involvement in small lymphocytic lymphoma (SLL)?
A) Peripheral blood
B) Lymph nodes
C) Bone marrow
D) CNS

Answer 13

B

Question 14

What is the most specific marker for classic hairy cell leukemia (HCL)?
A) CD23
B) CD103
C) Annexin A1
D) CD5

Answer 14

C

Question 15

What is the primary diagnostic method for CLL?
a) Bone marrow biopsy
b) Peripheral blood smear and immunophenotyping
c) MRI scan
d) PET scan

Answer 15

B

Question 16

What staging systems are used in CLL prognosis?
a) FAB and WHO
b) Rai and Binet
c) Ann Arbor
d) TNM

Answer 16

B

Question 17

What is the most powerful prognostic factor in CLL?
a) Age
b) IGHv mutation status
c) WBC count
d) Presence of smudge cells

Answer 17

B

Question 18

What is the approximate annual incidence rate of CLL in the U.S.?
a) 0.5%
b) 1.1%
c) 2.5%
d) 5%

Answer 18

B

Question 19

What is a common first-line treatment for CLL in the past?
a) Imatinib
b) Chlorambucil
c) Methotrexate
d) Hydroxyurea

Answer 19

B

Question 20

What is the preferred treatment for CLL patients with a TP53 mutation?
a) Chemotherapy alone
b) Targeted therapy (BTK, PI3K, BCL2 inhibitors)

Answer 20

B

Question 21

Which of the following is a BCL2 inhibitor used in CLL?
a) Dasatinib
b) Venetoclax
c) Everolimus
d) Pomalidomide

Answer 21

B

Question 22

Which leukemia is characterized by large atypical lymphoid cells?
a) CLL
b) Prolymphocytic Leukemia (PLL)
c) Hairy Cell Leukemia
d) Acute Lymphoblastic Leukemia

Answer 22

B

Question 23

What marker is highly specific for Hairy Cell Leukemia (HCL)?
a) CD3
b) Annexin A1
c) CD34
d) MPO

Answer 23

B

Question 24

Which type of leukemia is commonly associated with HTLV-1 infection?
a) CLL
b) Adult T-Cell Leukemia/Lymphoma (ATLL)
c) Burkitt Lymphoma
d) Follicular Lymphoma

Answer 24

B

Question 25

What cytogenetic abnormality is characteristic of Mantle Cell Lymphoma (MCL)? a) t(11;14) translocation b) t(9;22) c) t(15;17) d) t(8;14)

Answer 25

A

Question 26

What is the median age of diagnosis for Hairy Cell Leukemia? a) 40 years b) 50 years c) 60 years d) 70 years

Answer 26

C

Question 27

Which leukemia typically shows "flower cells" in blood smears? a) Adult T-Cell Leukemia/Lymphoma (ATLL) b) Burkitt Lymphoma c) Follicular Lymphoma d) Hodgkin Lymphoma

Answer 27

A

Question 28

Which lymphoma is associated with a "Starry Sky" appearance on histology? a) Burkitt Lymphoma b) Mantle Cell Lymphoma c) CLL d) Hodgkin Lymphoma

Answer 28

A

Question 29

What is a hallmark immunophenotypic feature of Sezary Syndrome? a) CD4+ T-cells with cerebriform nuclei b) CD8+ T-cells with convoluted nuclei c) CD10+ B-cells d) CD20+ B-cells

Answer 29

A

Question 30

Which lymphoma is most often associated with Epstein-Barr Virus (EBV)? a) Endemic Burkitt Lymphoma b) CLL c) Hairy Cell Leukemia d) Follicular Lymphoma

Answer 30

A

Question 31

Which lymphoma subtype has a high association with Hepatitis C infection? a) Mantle Cell Lymphoma b) Marginal Zone Lymphoma (MZL) c) Hodgkin Lymphoma d) Burkitt Lymphoma

Answer 31

B

Question 32

Which type of Hodgkin Lymphoma is the most common? a) Nodular Sclerosis b) Lymphocyte-Rich c) Mixed Cellularity d) Lymphocyte-Depleted

Answer 32

A

Question 33

What cell type is diagnostic for classic Hodgkin Lymphoma? a) Reed-Sternberg cells b) Smudge cells c) Centrocytes d) Hairy cells

Answer 33

A

Question 34

Which treatment is used for advanced-stage Hodgkin Lymphoma? a) CHOP b) ABVD regimen c) Imatinib d) Rituximab

Answer 34

B

Question 36

What is the 5-year survival rate for Hodgkin Lymphoma? a) 86% b) 50% c) 70% d) 30%

Answer 36

A

Question 37

Which B-cell lymphoma is considered highly aggressive but potentially curable? a) Burkitt Lymphoma b) Follicular Lymphoma c) Mantle Cell Lymphoma d) Marginal Zone Lymphoma

Answer 37

A

Question 38

What is the median age of diagnosis for Prolymphocytic Leukemia (PLL)? a) 40 years b) 50 years c) 70 years d) 60 years

Answer 38

C

Question 39

Which of the following genetic abnormalities is commonly seen in Follicular Lymphoma (FL)? a) t(9;22) b) t(14;18) c) t(15;17) d) t(8;14)

Answer 39

B

Question 40

What is the primary site of involvement in Small Lymphocytic Lymphoma (SLL)? a) Lymph nodes b) Peripheral blood c) Bone marrow d) Liver

Answer 40

A

Question 41

What staging system is commonly used for Hodgkin Lymphoma (HL)? a) Rai staging b) Ann Arbor staging c) Binet staging d) FAB classification

Answer 41

B

Question 42

What is the main clinical feature of Prolymphocytic Leukemia (PLL)? a) Peripheral lymphocytosis with smudge cells b) Aggressive disease with splenomegaly and high WBC count c) Mild cytopenia and indolent course d) Bone marrow fibrosis

Answer 42

B

Question 43

Which of the following lymphomas exhibits centrocytes and centroblasts in lymph node biopsy? a) Hodgkin Lymphoma b) Follicular Lymphoma (FL) c) Mantle Cell Lymphoma (MCL) d) Burkitt Lymphoma

Answer 43

B

Question 44

What histological appearance is seen in Burkitt Lymphoma (BL)? a) Reed-Sternberg cells b) Starry sky pattern c) Prolymphocytes d) Smudge cells

Answer 44

B

Question 45

Which leukemia is associated with villous lymphocytes? a) CLL b) Splenic Marginal Zone Lymphoma (SMZL) c) Hairy Cell Leukemia d) Acute Myeloid Leukemia

Answer 45

B

Question 46

What is a characteristic morphologic finding in Large Granular Lymphocytic (LGL) Leukemia? a) Abundant pale blue cytoplasm with azurophilic granules b) Cells with condensed chromatin and cleaved nuclei c) Giant multinucleated cells d) Cells with high mitotic index

Answer 46

A

Question 47

Which marker is typically negative in Splenic Marginal Zone Lymphoma (SMZL)? a) CD19 b) CD103 c) CD20 d) CD5

Answer 47

B

Question 48

What is the first-line therapy for Hairy Cell Leukemia (HCL)? a) Cladribine (2-CDA) b) Rituximab c) Venetoclax d) Imatinib

Answer 48

A

Question 49

What monoclonal antibody is used to treat T-cell Prolymphocytic Leukemia (T-PLL)? a) Rituximab b) Ibrutinib c) Alemtuzumab (anti-CD52) d) Blinatumomab

Answer 49

C

Question 50

What is the preferred treatment for Mantle Cell Lymphoma (MCL) patients who relapse? a) CHOP chemotherapy b) Ibrutinib (BTK inhibitor) c) Rituximab monotherapy d) CAR-T therapy

Answer 50

B

Question 51

Which targeted therapy is used for Waldenström’s Macroglobulinemia? a) Venetoclax b) Ibrutinib c) Methotrexate d) Bortezomib

Answer 51

B

Question 52

What is the standard treatment for aggressive Burkitt Lymphoma (BL)? a) CHOP b) Intensive chemotherapy (Hyper-CVAD, CODOX-M/IVAC) c) Low-dose radiation d) Watchful waiting

Answer 52

B

Question 53

What infection is strongly associated with Extranodal Marginal Zone Lymphoma (MALT type)? a) Helicobacter pylori b) Epstein-Barr virus c) Hepatitis C d) HIV

Answer 53

A

Question 54

Which lymphoma is most commonly associated with profound immunosuppression in HIV patients? a) Mantle Cell Lymphoma b) Burkitt Lymphoma (BL) c) Hodgkin Lymphoma d) Splenic Marginal Zone Lymphoma

Answer 54

B

Question 55

What lymphoma is associated with retroviral infection by HTLV-1? a) Adult T-Cell Leukemia/Lymphoma (ATLL) b) Follicular Lymphoma c) Diffuse Large B-Cell Lymphoma d) Chronic Lymphocytic Leukemia

Answer 55

A

Question 56

What is the primary site of involvement in Extranodal NK/T-cell Lymphoma? a) Bone marrow b) Nasal cavity c) Peripheral blood d) Lymph nodes

Answer 56

B

Question 57

What is the major complication seen in Waldenström’s Macroglobulinemia? a) Hyperviscosity syndrome b) Tumor lysis syndrome c) Bone marrow fibrosis d) Myelodysplasia

Answer 57

A

Question 58

What is the key difference between Hodgkin and Non-Hodgkin Lymphoma? a) Hodgkin Lymphoma primarily involves bone marrow b) Non-Hodgkin Lymphoma always follows an indolent course c) Hodgkin Lymphoma has Reed-Sternberg cells d) Non-Hodgkin Lymphoma only affects older adults

Answer 58

C

Question 59

Which subtype of Hodgkin Lymphoma is the most aggressive? a) Nodular Lymphocyte Predominant HL b) Lymphocyte-Depleted HL c) Mixed Cellularity HL d) Nodular Sclerosis HL

Answer 59

B

Question 60

Which Hodgkin Lymphoma subtype is most common? a) Lymphocyte-rich HL b) Nodular Sclerosis HL c) Mixed Cellularity HL d) Lymphocyte-Depleted HL

Answer 60

B

Question 61

Which of the following Non-Hodgkin Lymphomas has the highest cure rate with chemotherapy? a) Burkitt Lymphoma b) Follicular Lymphoma c) Marginal Zone Lymphoma d) Mantle Cell Lymphoma

Answer 61

A