Mata Flashcards
Heparin
Binds with AT3
Irreversibly inactivates thrombin
Neutralized by protamine
Does nothing if you have a AT3 mutation
Low Molecular Weight (LMW) Heparins
More selective so less side effects/bleeding
Enoxaprine
Dalteparine
Foundiparinoux
Heparin toxicity
HAT-Heparin interacts with platlets
HIT- Heparin interacts with Abs and can be life threatning
Other Anticoags
Rivaroxaban (Xarelto®) – Factor X inhibitor
Used to prevent DVT after Sx
Decreases Stroke risk if you have A.Fib
Direct thrombin inhibitors
End with Rudin
No Reversal agents
Lepirudin
Desirudin
Bivalirudin
Small Direct thrombin inhibitors
Argatroban- Use if HIT
Dabigatran- no drug interactions
WARFARIN (Coumadin®)
Against F2/7/9/10 C and S
Drug interactions with sulfonamides and aspirins
CYP2C9 metabolism
Clopidine
Can be given with loading dose or ASA
Increased CVA if good metabolizer
Ticlopidine
TTP, Aplastic anemia, neutropenia side fx
Prasugrel (Effient®)
Don’t give if Hx of TIA/Stroke
Ticagelor (Brilinta®)
Don’t give if Hx of TIA/Stroke
Plasminogen activators
Streptokinase (anistreplase)
TPA analogs
Plasminogen inactivators
Aminocaproic acid
Tranexamic acid
Dipyridamole (Persantine®) - oral
Dipyridamole + warfarin may be used to prevent thrombus on prosthetic heart valves
Dipyridamole + aspirin : ↓ incidence of thrombotic diathesis in pts.
Cilostazol (Pletal®) - oral
For PAD and Claudication
Dont give if they have CHF
