Condensed pharm reversed

Question 1

Condensed pharm reversed

Nitrogen mustards
Nitrosoureas

General- effect all phases, can be seen more in S phase

Answer 1

Alkylating subgroups

Question 2

Condensed pharm reversed

Mechlorethamine- Vesicant
Tx: Thiosulfate
Do not give if pregnant

Cyclophosphamide pro drug
Hemorrhagic cycstitis (give fluid and ESNA)
Leukopenia
SIADH (Give lasix)

Answer 2

Nitrogen mustards and side effects

Question 3

Condensed pharm reversed

Alkylates carbomoylate protein and attacks O2, and can cross BBBCarmustine- can cause pulmonary fibrosis

Answer 3

Nitrosoureas action, main drug and its side effect

Question 4

Condensed pharm reversed

Methotrexate
Give with low dose of leukovorin to rescue healthy cells
Can cause renal/neuro toxicity

Answer 4

Folic acid analog

Question 5

Condensed pharm reversed

Can cause Uric acid build up from xanthine oxidase
ARA-C is a deoxycytidine and fragments dbl helix via steric hindrance
Commonly given with vinblastine

Answer 5

Pyrimidine analogs and side effects

Question 6

Condensed pharm reversed

6-MP
6-TG
Fludarabine
Pentostatin
Cladribine and clofarabine

Answer 6

Purine analogs

Question 7

Condensed pharm reversed

Use with allopurinol because it reduces its metabolism and decreases uric acid levels

Answer 7

6-MP

Question 8

Condensed pharm reversed

Also use with allopurinol

Activatied by HGPRT

Answer 8

6-TG

Question 9

Condensed pharm reversed

FATAL PULMONARY TOXICITY if given with Fludarabine

Answer 9

Fludarabine

Question 10

Condensed pharm reversed

FATAL PULMONARY TOXICITY if given with Pentostatin

Answer 10

Pentostatin

Question 11

Condensed pharm reversed

Reduce NAD and ATP

Answer 11

Cladribine and Clofarbine

Question 12

Condensed pharm reversed

M Phase specific
Binds tubulin
Disrupts transport=NeurotoxinResistance if P-gp gene amplified
Death if given intrathecally
Extreme pain fon extravasastion from phlebitis

Vincristine
Vinblastine

Answer 12

Vinca alkaloids side effects and drugs

Question 13

Condensed pharm reversed

In MOPP regimen

Answer 13

Vincristine

Question 14

Condensed pharm reversed

Give with ARA-C, gets stuck in S phase and ARA-C becomes more effective
Can cause SIADH

Answer 14

Vinblastine

Question 15

Condensed pharm reversed

Binds tubulin, does not effect structure
Prevents re-annealing of cells in S and G2 phases

Etopiside- Mild thrombocytopenia
Teniposide- Longer duration

Answer 15

Topo 2 inhibitors

Question 16

Condensed pharm reversed

All with rubicin in the name
Intercalates between opposite DNA strands, they then break
CARDIOTOXIC: Use with dexrazoxane

Answer 16

Anthracycline side fx and drugs

Question 17

Condensed pharm reversed

VESICANT with Adriamycin flare streaking
Causes red urine and leukopenia

Cardiotoxitiy-Quinones attached to the anthracycline ring form semiquinones that chelate iron forming an Rx-Fe-DNA complex that reacts with O2

Answer 17

Doxorubicin

Question 18

Condensed pharm reversed

Like doxorubicin but with a limited spectrum

Answer 18

Daunorubicin

Question 19

Condensed pharm reversed

Mitoxanthrone

Bleomycin

Answer 19

End anthracyclines

Question 20

Condensed pharm reversed

Less toxic than Bleomycin

Answer 20

Mitoxantrone

Question 21

Condensed pharm reversed

PULMONARY FIBROSIS and CUTANEOUS problems

Chelates copper and iron

Answer 21

Bleomycin

Question 22

Condensed pharm reversed

Anaphylaxis
Hyperglycemia
Bleeding

Answer 22

L-Asparaginase

Question 23

Condensed pharm reversed

Azacitidine
Decitabine
Nelarabine

Answer 23

DNA methylating agents

Question 24

Condensed pharm reversed

Covalently binds to DNA cytosine methyltransferaseLeads to apoptosis

Answer 24

Azacitidine

Question 25

Condensed pharm reversed

Like azacitidine but also breaks DNA strand

Answer 25

Decitabine

Question 26

Condensed pharm reversed

Alemtuzumab- CD52

Tositomomab- kills via ionizing radiation

Answer 26

Monoclonal IgG antibodies end with mab

All target CD20 except the A one

Question 27

Condensed pharm reversed

Aggravating fatal neuropsychiatric, autoimmune, ischemic, and infectious disorders

Alpha 2a (inhibits ornithine decarboxylase), peg2a, alpha 2b

Answer 27

Interferons BBW

Question 28

Condensed pharm reversed

Acts on T cell progenitors to make LAK

CAPILLARY LEAK SYNDROME

Answer 28

Aldesleukin

Question 29

Condensed pharm reversed

IL2 with Diptheria toxin

CAPILLARY LEAK SYNDROME

Answer 29

Denileukin difitox

Question 30

Condensed pharm reversed

t9;22  with Ph chromosome 
Imitiinab
Nilotinib
Dasatinib 
Pronatinib- BBW
Ibrutinib- prevents -cell trafficing

Answer 30

BCR-ABL protein TK inhibitors

Question 31

Condensed pharm reversed

Thrombosis and hepato toxicity

Answer 31

Pronatinib BBW

Question 32

Condensed pharm reversed

S phase specific

Answer 32

Hydroxyurea

Question 33

Condensed pharm reversed

RAR-RXR bindingInhibits proliferation

Do not give if pregnant

Answer 33

Tretinoin

Question 34

Condensed pharm reversed

DNA fragmentation

Answer 34

Arsenic trioxide

Question 35

Condensed pharm reversed

Inhibits ubiquitin pathway

Answer 35

Bortezomib

Question 36

Condensed pharm reversed

Inhibits angiogenesis, decreases TNFa and leukocyte migration

Answer 36

Thalidomide

Question 37

Condensed pharm reversed

Like thalidomide just not as teratogenic

Answer 37

Lenalidomide

Question 38

Condensed pharm reversed

Do not give if pregnant.

Answer 38

Pomalidomide