Mat P1 Flashcards
What is an abortion? What is considered viable? What is it after this?
is a medical term for any interruption of a pregnancy before a fetus is viable (20-24 wks of gestation or one that weighs at least 500g). a fetus born before this point is considered a miscarriage or is termed a premature or immature birth.
time frame for early vs. late miscarriage?
when is bleeding more of a problem and why?
early- week 16
late- 16-24
week 12+ because placenta is imbedded in uterus and it is more life threatening
% of spontaneous abortions in pregnancies?
15-30%
what are torc infections?
they are associated with inc risk of spontaneous abortions
Toxoplasmosis- cat litter/feces
Other- chicken pox
Rubella- immune? There is an inc risk of SA and fetal affects to death to mental retardation or systemic rash
Cytomegalo virus
Herpes
What are some other causes of spontaneous miscarriages?
abnormal fetal development d/t teratogenic, immune system response, corpus letup does not produce enough progesterone, alcohol, UTI, systemic infections cause sloughing of endometrium
what is antiphospholipid antibody syndrome?
it is an autoimmune disease that occurs more freq in women than in men. Abnoral protein (antiphospholipid autoantibodies) initiate coagulation and so lead to clotting in arteries and veins. If this occurs in placental vessels- blocks placenta growth and thrombi can loosen the placenta and interfere with o2 and nutrient exchange
how do you treat antiphospholipid antibody syndrome?
o Prophylaxis therapy to prevent miscrriages is oral low dose aspiri and subcu heparin started at beginning of pregnancy
o Alt therapies- IV immunoglobulin infusions or administration of a corticosteroid such as prednisone can be added if heparin and aspirin are not adequate.
`
what are some postpartum risks for antiphospholipid Ab syndrome?
DVT
clotting inc w bed rest, smoking, obesity and birth control pills
what is the result of antiphospholipid Ab syndrome?
recurrent miscarriage or hypertension in preg
what are some complications of miscarriage?
hemorrhage, infection, septic abortion (abortion d/t infection), isoimmunization (ab against rh positive blood
what is an ectopic pregnancy?
implantation occurs outside the uterine cavity. (most commonly the fallopian tube in the ampler area- distal portion)
where can fertilization occur in an ectopic pregnancy?
o Fertilization still occurs in the distal third of the fallopian tube but there is an obstr present such as an adhesion of the fallopian tube from a previous infection, congenital malformations, scars from tubal surgery or a uterine tumor pressuing on the proximal end of the tube, the zygote cannot travel the length of the tube
if you have one ectopic pregnancy can you have another? why or why not?
o If you have on ectopic preg more likely to have another, because salpingitis general leaves scarring which is bilateral.
S&S of ectopic preg?
sharp, stabbing pain in one of her lower abdm quadrants at the time of the rupture, followed by scant vaginal spotting. (amount doesn’t indicate amount lost)
what are you at risk for in ectopic preg?
inc blood los- hypovolemic shock
what happens if you wait too long after ectopic pregnancy before getting help?
abdm becomes rigid from peritoneal irriation and umbilicus may develop a bluish- tinged hue (Cullen sign)
Tx for ectopic preg?
some spont end before the rupture and are reabsorbed over the next few days requiring no tx.
• Usually treated by PO med of methotrexate. Adv: tube is left intact with no surgical scarring that oculd cause a 2nd ectopic implantation
• Therapy is laparoscopy to ligate the bleeding v and remove or repair damaged fallopian tube. A rough suture on tube may lead to another tubal preg so either tube is removed or suturing is done microsurgical technique. If tube removed she is 50% fertile. Not reliable cause ova can still move to other tube and fertilize there.
if a woman comes in with an ectopic pregnancy, how do you get the EBL?
not just the external blood loss. get a Hgb, RBC, Hct lab done and might have to cross match
what is gestational trophoblastic disease? (hydatidiform mole)
o Abnormal proliferation and then degernation of the trophoblastic villi. As the cells degenerate they become filled with fluid and appear as clear fluid-fille, grape sied vesicles. The embryo fails to develop beyond a primitive start.
why is it important for (hydatidiform mole) cells to be identified?
because they are associated with choriocarcinoma, rapid mets malignancy
who is more likely to get (hydatidiform mole)?
1 in 1500
o occurs more often in low protein diets and woman older than 35 and of Asian heritage and blood group A and may blood group O men
assessment of (hydatidiform mole)?
• uterus tends to expand faster than usual or the uterus reaches its landmarks (just over symphysis brim at 12 wks and umbilicus at 20-24) before usual time
- gestational htn may present before wk 20
- US shows dense growth but no fetal growth
- at wk 16- if structure not identified might show through vaginal bleeding starting as dark red or perfuse fresh flow then clear fluid vesicles.
tx of • hydatidiform mole)?
suction curettage to evacuate the abnormal trophoblast cells. Following extraction women should have a baseline pelvic exam and a serum test for the beta subunit of hCG and hcg checked q2k until levels are normal. Then q4wk for next 6-12mths to see if declining
if a woman passes clear vesicles, what does this mean?
might have hydatidiform mole (gestational trophoblastic disease)
what is occurring at a cellular level in gestational trophoblastic disease?
o A partial mole has 69 chr. (69XX, 69XY) – 3 chr for every pair instead of 2 (triploid formation). One egg fertilized by 2 sperm or ovum fertilized by one sperim in which meiorsis or reduction division did not occr.
which type of mole is more likely to turn into cancer?
complete moles more likely lead to choriocarcinoma rather than partial
in gestational trophoblastic disease, will your hCG be high or low?
it will still be high because the trophoblastic cells release hCG until about day 100
in gestational trophoblastic disease, will you still have n + V?
yes, most likely from hCG
Tx of gestational trophoblastic disease?
suction curettage to evacuate the abnormal trophoblast cells. Following extraction women should have a baseline pelvic exam and a serum test for the beta subunit of hCG and hcg checked q2k until levels are normal. Then q4wk for next 6-12mths to see if declining
if your hCG level (following evac of cells) plateaus or inc, what could this mean?
malignant transformation aka choriocarcinoma
what is cervical insufficiency?
it is premature cervical dilation and cannot retain the fetus
when does cervical insufficiency occur?
around week 20 and fetus is too immature
symptom of cervical insufficiency?
• Painless and 1st sympt is show (pink-stained vaginal disch) or inc pelvic pressure which is then rupture of membranes and dichar of amniotic fluid
what is the treatment or procedure for cervical insufficiency?
cervical cerclage surgery following the loss to prevent this from happening again.
• As soon as US confirms fetus of second preg is healthy at 12-14 wk purse string sutures are placed in the cervix by the vaginal route under regional anesthesia. Procedure is called a mcdonalf or shirodkar procedure. Sutures strengthen the cervix and prevent it from dilating
what is the difference between Mcdonald and Shirdokar in cervical insufficiency?
- Mcdonald- nulon sutures are placed horizontally and vertically across cervix
- Shirodkar0 sterile tape is threaded in a purse-string mane ruder submucos layer of the cervix and sutured in place to achieve a closed cervix. Can be done by transabdominal route
what nursing care can you do following a cervical cerclage surgery?
keep women in trendelenburg position for a few days to dec pressure on new sutures
what is placenta previa?
where the placenta is implanted abnormally in the lower part of the uterus. most common cause of painless bleeding in the 3rd trimester
what are the different degrees placenta previa can occur?
implantation in the lower, rather than the upper part of the uterus (low-lying placenta), marginal implantation (the placenta edge approaches that of the cervical os), implantation that occludes a portion of the cervical os (partial placenta previa), and imlentation that totally obstructs the cervical os (total placenta previa)
why is placenta previa a life threatening condition?
it can cause hemorrhage
in placenta previa, why should you not do a internal exam?
because placenta might be covering cervix and could rupture
how is the baby delivered in placenta previa?
some can be vaginal but most C/S
what drug might you give the mom before C/S for placenta previa?
betamethasone IM to increase fetal surfactant
in a patient with placenta previa, should you be worried about a little bleeding from vagina?
yes, can be life threatening to fetus
epidiemology of placenta previa?
5in 1000 births
why would bleeding occur in placenta previa?
o Bleeding doesn’t usually begn until the lower uterine segment starts to differentiate from the upper segment late in the pregnancy (approx. wk 30) and cervix begins to dilate. Bc the placenta is unable to stretch to accommodate the differing shape of the lower uterine segment or the cervix, small portion loosens and damaged blood vessels begin to bleed.
what is abruption placentae?
premature separation of the placenta. the placenta is implanted correctly but begins to separate and bleeding results. Part of the placenta peels away from the uterine wall and blood is still being delivered to uterus and collects in space or comes out of the vagina (hidden bleeding –occult or obvious bleeding that comes out) some of the babies blood escapes
what are risks of abruption placentae
unknown causes. high parity, older age, short umbilical cord, chronic htn disease, htn of preg, direct trauma, vasoconstriction from cocaine or cigarette use and thrombophilitic conditions that lead to thrombosis formation. Or chorioamniotisi or infections of the fetal membranes and fluid
what is the most common cause of perinatal death?
aburtpio palcentae
what is the epidemiology of abruptio placentae?
10% of pregnancies
S&S of abruptio placentae?
usually occurs late in pregnancy or during labour, sharp, stabbing pain at fundus, tender uterus on palpation, heavy bleeding unless concealed, may be dark in colour, uterus becomes rigid, boardlike (COUVELAIRE uterus)
what bloodwork do you want for patient with abruptio placentae?
clotting time, platelets, cross match to prepare
is the delivery of fetus quick or slow in abuptio placentae?
very fast
Tx for abuptio placentae?
IV fluid monitor FHR and vitals keep in lateral no spine to prevent p on vena cava and fetal circulation preg must be terminated unless C/S Grading scale 0-3 ?
what is the epidemiology of preterm labour?
9-11% of pregnancies. responsible or 2/3 of all neonatal deaths