Mast Cell and Eosinophil-mediated Hypersensitivity Flashcards
Define Type I hypersensitivity. What are the 3 cells types that are invovled?
What are the triggers of type 2 responses?
What’s the term for excessive production of IgE?
What interleukins are produced by Th2 cells in type 2 immune responses?
Which interleukins can inhibit IL4?
Where are the two types of FceRI receptors located? What’s the significance?
What’s the role of FceRII (CD23) receptors in allergic reaction?
Compare and contrast the 2 types of T cells.
What happens when the TLRs are triggered in mast cells? by bacteria, by lipopolysaccharides?
Describe the cascade of reaction leading to granule exocytosis when mast cell is triggered by IgE cross-linked antigen.
Name the 3 major effects of IL-33.
Describe the 2 catecholamine receptors on mast cells and how pharmaceuticals can enhance or inhibit mast cell degranulation.
What are the effects on smooth muscles and blood vessels when the catecholamine receptors on mast cells are stimulated?
How does epinephrine’s alpha and beta adrenergic activity help with type I allergic reaction?
How does mast cell help with infections?
What are the 2 phases of allergic reaction? What are they mediated by?
Basophil granules are similar to that of mast cells. What granule does it have that is 10,000x more potent that heparin in vascular permeability?
What type of immune response involves basophils?
How does mast cells and Th2 cells stimulate the release of eosinophils from the bone marrow?
What’s the role of eosinophils in allergic reactions?
What role does eosinophils play in humoral immunity?
