Mast Cell and Eosinophil-mediated Hypersensitivity

Question 1

Define Type I hypersensitivity. What are the 3 cells types that are invovled?

Question 2

What are the triggers of type 2 responses?

Question 3

What’s the term for excessive production of IgE?

Question 4

What interleukins are produced by Th2 cells in type 2 immune responses?

Question 5

Which interleukins can inhibit IL4?

Question 6

Where are the two types of FceRI receptors located? What’s the significance?

Question 7

What’s the role of FceRII (CD23) receptors in allergic reaction?

Question 8

Compare and contrast the 2 types of T cells.

Question 9

What happens when the TLRs are triggered in mast cells? by bacteria, by lipopolysaccharides?

Question 10

Describe the cascade of reaction leading to granule exocytosis when mast cell is triggered by IgE cross-linked antigen.

Question 11

Name the 3 major effects of IL-33.

Question 12

Describe the 2 catecholamine receptors on mast cells and how pharmaceuticals can enhance or inhibit mast cell degranulation.

Question 13

What are the effects on smooth muscles and blood vessels when the catecholamine receptors on mast cells are stimulated?

Question 14

How does epinephrine’s alpha and beta adrenergic activity help with type I allergic reaction?

Question 15

How does mast cell help with infections?

Question 16

What are the 2 phases of allergic reaction? What are they mediated by?

Question 17

Basophil granules are similar to that of mast cells. What granule does it have that is 10,000x more potent that heparin in vascular permeability?

Question 18

What type of immune response involves basophils?

Question 19

How does mast cells and Th2 cells stimulate the release of eosinophils from the bone marrow?

Question 20

What’s the role of eosinophils in allergic reactions?

Question 21

What role does eosinophils play in humoral immunity?