Mast cell

Question 1

Compare and contrast the location and function of basophils and mast cells

Answer 1

Both types of cells mediate allergic reactions and secrete histamine; however, mast cells bind immunoglobulin E and are found in tissue, whereas basophils are found in the blood

Question 2

What substances are released when mast cells degranulate?

Answer 2

Histamine, heparin, eosinophilic chemotactic factors

Question 3

What stimulus causes mast cell degranulation?

Answer 3

Immunoglobulin E binding to receptors on the surface of the mast cell

Question 4

You note many basophils on a peripheral smear of a patient undergoing an allergic reaction; do you also expect to see mast cells?

Answer 4

No; although both cells are involved in allergic reactions, basophils are found in the blood whereas mast cells are typically only found in tissues

Question 5

What medication can prevent the release of inflammatory compounds from mast cells in a patient with asthma?

Answer 5

Cromolyn sodium, which stabilizes mast cell membranes and prevents degranulation

Question 6

T/F. Mast cells contain basophilic granules and originate from the same precursor as basophils and are the same cell type

Answer 6

False; mast cells contain basophilic granules and originate from the same precursor as basophils but are not the same cell type

Question 7

Mast cells are involved in what type of hypersensitivity reaction?

Answer 7

Type I hypersensitivity