Basophil

Question 1

What distinguishes the appearance of a basophil from other granulated cells?

Answer 1

The densely basophilic granules, which stain blue with basic stains

Question 2

What molecules, normally seen as part of the inflammatory cascade, are contained in basophilic granules?

Answer 2

Histamine (which causes vasodilation) and other vasoactive amines, as well as leukotrienes (LTD-4)

Question 3

Compare and contrast the function and location of basophils and mast cells

Answer 3

Both types of cells mediate allergic reactions and secrete histamine; however, mast cells bind immunoglobulin E and are found in tissue, whereas basophils are found in the blood

Question 4

You note many basophils on a peripheral smear of a patient undergoing an allergic reaction; do you also expect to see mast cells?

Answer 4

No; although both cells are involved in allergic reactions, basophils are found in the blood whereas mast cells are typically only found in tissues

Question 5

Basophilia is uncommon, but can be a sign of ____

Answer 5

Myeloproliferative disease, particularly CML