Mass Transport Ch.7 Flashcards
The structure of Haemoglobin
A protein molecule with a Quaternary structure. Has 4 polypeptides. Each polypeptide is attached to Fe2+ ion. Each Fe2+ ion can bind with one O2. A total of 4 O2 can bind to haemoglobin.
What is the equation for haemoglobin loading
haemoglobin + oxygen = oxhaemoglobin
What is the equation for heamoglobin dissociating
oxhaemoglobin = haemoglobin + oxygen
What is high affinity for O2
O2 is readily taken up but releases it less easily
What is low affinity for O2
O2 is released readily but taken up less easily
What is the role of haemoglobin
To transport oxygen
Where does O2 readily dissociate?
Places where oxygen is required and concentration of oxygen is low (tissues ) E.g. muscles
Where does O2 readily associate with oxygen?
At the surface of gas exchange, where oxygen concentration is high. E.g lungs
What is partial pressure of oxygen?
The concentration of oxygen. the hypothetical pressure of oxygen if it alone occupied the entire volume
How does the concentration of CO2 relate to the pH?
The higher the CO2 concentration the lower the pH.
How does the pH relate to the structure of haemoglobin?
When the pH lowers the shape/structure of haemoglobin changes and the affinity for oxygen lowers. pH high= higher affinity
High CO2 concentration has low or high affinity?
Low affinity
Low CO2 concentration has low or high affinity?
High affinity
Explain the shape of the oxygen dissociation curve?
First O2 is hard to bind because of the shape of haemoglobin. After first binds the Quaternary structure changes and 2nd and 3rd O2 binds easier. The 4th O2 is hard to bind too because there is less chance for the O2 to bind to a free iron.
What does it mean if the oxygen dissociation curve is more to the right?
Lower affinity in general, realises oxygen more readily
What does it mean if the oxygen dissociation curve is more to the left ?
Higher affinity in general, binds with oxygen more readily.
Define Mass Transport
Large scale transport of substances through a transport system to and from exchange surfaces.
What determines whether an organism needs a specialised transport system or a pump.
Surface area: volume ratio (lower=bigger organism=needs specialised system+pump). More active= needs specialised system+ pump.
Hepatic is?
Liver
Renal is?
Kidney
Explain the route the blood takes on the right side of the heart?
(superior/inferior) vena cava
How do valve work?
By difference in blood pressure
What is the use of valves?
To prevent backflow
Where are the Atrioventricular valves?
Valves between the arteries and ventricle
Where are the Semi-lunar valves?
After the ventricle, in the aorta and pulmonary artery
Whats the name of the blood vessel that supplies blood to the heart?
coronary artery
What is systole?
contract
What is diastole?
Relaxing