MAOIs and TCAs Flashcards
Which MAOI is stimulating?
Tranylcypromine= Parnate
it is non hydrazine
structurally related to stimulants
Wellbutrin also looks like amphetamine
Which TCA is least anticholinergic?
most?
desipramine then nortryptiline
TAC=trimipramine, amitryptiline, clomipramine
Which TCA is least sedating?
most?
desipramine, protriptyline
TAD=trimipramine, amitryptilin, doxepin
Which TCA is least orthostatic hypotention?
Most?
Nortriptyline
Imipraine is the worst, but also: TAC and desiramine
Which TCA is the most stimulating
desipraine, protriptyline
Which TCA is the most EPS?
amoxapine
Which TCA has most conduction abnormalities
Trimipramine is the worst.
TAC and protriptiline
Medical # to MAOI
CHF, phaepchromocytoma, liver disease
Ok with Maoi
Methadone
Buprenorphin
Lamotrigine
Not meperidine, fentanyl
Not carbamazepine
with methadone
2d6-
Zidovudine
Desiptamine
Luvox
dietary restriction with moclobemide?
no
sibutramine?
SNRI fot wt loss
fenfluramine
serotonergic, off market due to valvular abN
slegeline limits of selectivity
transdermal above 6 mg inhibits gut MAOI and needs dietary restriction
and above 20 it blocks A as well as B
RIMA indications and SE
- indications: atypical depression, severe depression, treatment-resistant depression
- side effects: insomnia, dizziness, agitation, anxiety, restlessness, dry mouth, N/V, galactorrhea, rarely hypertension
- weight gain is unusual
- MAOIs are useful in bulimia
- RIMAs cause fewer GI effects than SSRIs
- moclobemide does not have anticholinergic or CV effects and does not interfere with sexual function
