interactions Flashcards
3 drugs that INCREASE with carbamazepine
phenytoin
topiramate
clomipramine
weird SE with oxcarbazepine?
hyponatremia
Metabolism of Warfarin?
SSRIS that increase its effect 3?
mainly 2C9, but also 1A2, 3A4
mainly Luvox, but also paroxetine and sertraline(latter also ny protein displacement)
warfarin may be an inducer?
TCA metabolism
tiertiary: I’m Clom’s Ami (impramin, clomipramine, amitryptiline) by all enzymes except 2D6
secondary ( desipramine, nortryptiline) by 2D6
Cyp polymorphisms for?
2D6
2C19
clozapine increased by
caffiene stoping smoking grapefruit luvox protease inhibitors erythromycin
3A4 antiderssant inhibitors
fluvoxamine
fluoxetine
nefazodone
drugs that raise benzos
-BDZs are increased by: cimetidine, disulfiram. Isoniazid, estrogen/OCP
luvox efect on celexa
increases celexa though 2 c19 inhibition
notes: all SSRI proteinbound, Clexa and Luvox and especially escitalopramthe least
AA interactions
Smoking –decreased plasma level of clozapine and olanzapine by 20-100% due to induction of metabolism (1A2)
Fluoxetine-paroxetine-fluvoxamine-sertraline: increased plasma level of antipsychotic 76%
increase clozapine with fluoxetine, 2-7 fold and 40-50% increase with paroxetine or sertraline
Grapefruit juice-increased plasma level of quetiapine due to inhibition of metabolism via CYP 3A4, data contradictory with Clozapine
what is rifampicin
inducer
affects antidepressants
duloxetine metabolized by?
1A2
Luvox on statins, warfarin
increases both
fluoxetine on TCA, beta blockers
increases both, 2D6
paroxetine and sertraline effect on CCB, digoxin, anticancer agents
inhibit p glycoprotein
increased levels
