Question 1

3A4 inhibitors

Accepted Answer

``` Nefaozodone Fluvoxaine Fluoxetine grapefruit juice Antiretrovirals antibiotics (macrolide like erythromycin) Antifungals (like ketoconazole) CCB ```

Question 2

3A4 inducers

Accepted Answer

``` carbamazepine phenytoin barbiturates modafinil rifampicin efavirenz st John's wort ```

Question 3

3A4 substrates

Accepted Answer

``` Benzos many antipsychotics Carbamazepine OCP statins antiretrovirals immunosuppressants antineoplastic cortecosteroids CCB ```

Question 4

1A2 inhibitors

Accepted Answer

``` fluvoxamine caffiene ciprofloxacin estrogen cimetidine Atazanavir ```

Question 5

1A2 inducers

Accepted Answer

``` carbamazepine ?phenytoin barbiturates rifampicin primidone smoking (not St.John's wort which induces 3A4, 2C9, 2C19) ```

Question 6

1A2 substrates

Accepted Answer

``` Clozapine Olanzapine Mirtazapine Ropinirole Warfarin Theophyline caffiene ```

Question 7

2D6 inhibitors

Accepted Answer

``` Paroxetine Fluoxetine Sertraline Duloxetine Buproprion ``` Terbenafine (antifungal) Imatinib (anti-leukemia) Quinidine (antiarrythmic) Amiodarone (antiarrythmic) there are poor metabolizers

Question 8

2D6 inducers

Accepted Answer

none! but there are ultra-rapid metabolizers

Question 9

2 D6 Substrates

Accepted Answer

``` antidepressants: TCA SSRI SNRI Trazodone ``` AA: Risperidone Abilify ``` FGA: Haldol chlorpromazoine perphenazine zuclopenthixole ``` betablockers propranolol metoprolol anti-arrythmic: flecainide mexiletine

Question 10

activation by 2D6 inhibitors of 2 D6 prevent drug from working

Accepted Answer

codeine tramadolhydrocodone tamoxifen

Question 11

2C9 inhibitors

Accepted Answer

Valproate Disulfiram Fluoxetine Clopidogrel (also 2C19-) Amiodarone (also 2d6-) Fluconazole (also 2C19-) metronidazole

Question 12

2C9 inducers

Accepted Answer

``` carbamazepine phenytoin barbiturates rifampicin Efavirenz (also 3A4 +) St.John's wort (also 3A4+) ``` all of these are 3A4 inducers

Question 13

2C9 substrates

Accepted Answer

``` phenytoin barbiturates Warfarin Glyburide (DM) Glipizide (DM) NSAIDs ARB ```

Question 14

2C19 inhibitors

Accepted Answer

``` Fluoxetine Fluvoxaine Moclobemide Modafinil (also a 3A4 inducer) Oxcarbazepine ``` Clopidogrel (2C9-) Efavirenz (+ of 2C9 and 3A4) Omeprazole Fluconazole (2C9 -)

Question 15

2C19 inducers

Accepted Answer

``` carbamazepine phenytoin barbiturates rifampicin st Johns wort ``` same as 3A4 and 2C9 inducer list (minus modafinil and efavirenz)

CYP 450 interactions Flashcards