Mantle cell lymphoma Flashcards
1
Q
mantle cell lymphoma background
A
over expression of cyclin D1 - cell cycle regulator
present with advanced disease
aggressive
incurable
2
Q
local indolent disease
A
sub group
young
normal LDH
no B symptoms
therapy can be delayed until symptoms develop
3
Q
treatment
A
Basis of therapy is R-CHOP
success with more aggressive regimes
R-hyper CVAD cyclophosphomide vincristine adriamycin (doxorubicin) dexamethasone
cytarabine
methotrexate /leucovorin
4
Q
Relapsed Disease
A
Auto SCT
