Burkitt lymphoma Flashcards
burkitt lymphoma basics
highly aggressive B cell non-Hodgkin lymphoma characterized by the translocation and deregulation of the c-MYC gene
MYC protein transcription factor. This transcription factor modulates the expression of target genes that regulate many cell processes including cell growth, division, Warburg metabolism, and cell death by apoptosis.
Epidemiology
common in children
uncommon in adults
3 distinct types
- Endemic – The endemic variant is found in equatorial Africa and New Guinea.
Associated with EBV - Sporadic
- Immunodeficiency-associated
more common in males
Patients with BL present with rapidly growing tumor masses and often have evidence of spontaneous tumor lysis with a very high serum lactate dehydrogenase (LDH) concentration and elevated uric acid levels. The tumor doubling time is very short
Treatment
Patients with BL re
quire intensive, frequent multi-agent therapy with adequate CNS prophylaxis
incorperate rituximab
no agreed upon regime
recommend R-CODOX-M/IVAC
HIV associated Burkitts
clinically difficult due to immunocompromised state
(ART) is started or modified (if already begun) to control the HIV infection and allow for the administration of chemotherapy and/or radiation therapy
