Management Flashcards
Lowering Insulin resistance drug type
Thiazolidinediones
Amplifier of insulin
Incretins,
GLP
Glucose like polypeptide
GIP
Glucose dependent insulinotropic polypeptide
Lowering post-meal; reducing appetite; insulin like
Amylin analogue
Lowering complex sugar absorption and digestion
Alpha goucosidase inhibitors
Drug that activate AMPK
Metformin
Metformin other name
Biguanides
Metformin dosage
500 - 2550 mg / day; <1000mg direct
Contraindications for metformin
Renal; alcohol ; hepatic disease
Insulin secretagogue type of drugs
Sulphonylurea; meglitinde; d-ohenylalanine derivates
Sulphonylurea mechanism of action
Inhibits efflux potassium ions, efflux Ca, stimulates insulin release
1st gen sulphonylurea
Tolbu-; chlorpro-; lolaza-; MIDE
Contraindications of sulphonylurea
Cardiovascular diseases in elderly persons; hypoglycemia
2-binding sites sulphonylurea alike
Meglinitide, repaglinide
Rapid sulphonylurea
Nateglinide
2nd gen of sulphonylureas
Glybur-; glipiz-; glimepr-; -IDE
Thiazolidinediones mechanism of action
Ligands to peroxisome activated receptor gamma (PPAR gamma)
PPAR gamma mechanism of action
Alter carbohydrate and lipid metabolism; modulated insulin transduction; increase adipocyte and tissues differentiation
TZD drug name
Progliti-; rosiglita-; -ZONE
TZD contraindications
Pregnancy; heart failure; fluid retention; weight gain
Alpha glucosidase inhibitors mechanism of action
Competitive inhibitor of carbohydrate digestion-enzyme
A-glucosidase inhibitors drug name
Aracbise and migitol
A-glucosidase inhibitors contraindications
Inflamm bowel disease
A-glucosidase inhibitors dosage
25-100 mg/premeal
GLP drug name
Exena-; loragla-; -TIDE
Contraindications of GLP-1
Pancreatitis
DDP-4 agonists
Dipeptidyl peptidase-4
DDP-4 name of drug
Sitag-; saxa-; linag-; -LIPTIN
