Mammography Flashcards

1
Q

Why is mammography technically demanding, requiring dedicated equipment?

A

There is little difference in the properties and, therefore, contrast of different tissues within the breast. Detecting cancers requires the distinguishing of small (e.g. ~ 0.1 mm microcalcifications), low contrast objects.

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2
Q

How is the geometry of a mammography examination different to that use in general radiography?

A
  • Geometry is generally fixed for mammography examinations (i.e. on breast on the support table), except for magnification modes (i.e. breast on magnification platform).
  • The geometry is such to make use of the anode-heel effect (reduced intensity towards the nipple edge).
  • The position of the focal spot relative to the image receptor is different. It resides almost directly above the chest wall edge of the detector with collimation applied to cut off the beam at the chest wall edge (at what would have been the centre of the beam). This provides an asymmetric diverging beam to ensure no missed tissue at the chest wall edge and also no exposure to organs at risk (e.g. heart).
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3
Q

What are the differences between a mammography x-ray tube and a general radiography x-ray tube?

A
  • A smaller focal spot is required to detect smaller objects (0.3 mm or 0.15 mm for magnification compared to 1-1.2 mm for general radiography).
  • Low tube voltage (25-35 kVp) to maximise contrast and, therefore, the ability to detect low contrast objects.
  • W, Rh or Mo (less common) target materials are used compare to just W in general radiography.
  • Greater range of filtration materials (Mo, Rh, Ag, Al) compared to general radiography (Al, Cu).
  • Position of focal spot relative to the detector means the anode-heel effect can be used to reduce intensity towards the nipple edge where there is less tissue.
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4
Q

What does target/filter combination selection depend on in mammography?

A
  • Unit manufacturer/model.
  • Characteristics of breast being imaged.
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5
Q

What is the function of the filter in mammography?

A
  • Removes low energy photons to reduce skin dose. This also increases the mean energy of the beam and, therefore, reduces contrast.
  • To tailor the photon energy spectrum using the material K-edge (i.e. variations in the probability of a K-shell photoelectric interaction, and therefore photon attenuation, across the photon energy range).
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6
Q

How is the target/filter combination selected to tailor the photon energy spectrum?

A
  • The target is selected to produce characteristic lines at specific energies to match the breast being imaged. For one of the most common target materials (W), characteristic lines reside outside of the tube’s energy range to remove their effect.
  • The filter is typically selected to have a K-edge just below the target’s characteristic meaning they are transmitted well. Above the K-edge, significant attenuation of Bremsstrahlung photons is apparent, thus improving image contrast. Variations of target/filter combination can vary the above effects to match the breast being imaged.
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7
Q

Why is compression applied in mammography?

A
  • Immobilises the breast, preventing motion artefacts.
  • Reduces dose to the breast - a thinner volume of requires lower exposure factors and less scatter dose will also be apparent.
  • Improves image quality due the reduction in scatter and reduction in geometric unsharpness (due to objects being further from the image receptor).
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8
Q

What will happen to the collimation on most mammography systems when a compression paddle is attached?

A

Collimation will automatically change to the size and shape of the paddle.

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9
Q

What is pre-compression?

A

Some systems will allow a small amount of initial compression to hold the breast in place and allow for final positioning by the operator before full compression is applied.

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10
Q

How are the non-uniformities of the breast accounted for in compression on most mammography systems?

A

Flexible or titling paddles allow for more uniform compression.

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11
Q

How are smaller breasts positioned more easily on some systems?

A

Left-right shifting paddles allow for easier positioning of smaller breasts. Collimation will track the shift in paddle position.

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12
Q

How is compression optimised in some mammography systems?

A

The compressibility of breast tissue is analysed to determine the optimum compression force as a trade-off between patient discomfort, dose and image quality.

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13
Q

What safety systems are in place for compression in mammography?

A
  • Auto compression release post-exposure.
  • Limits to the levels of automatic and manual compression that can be applied.
  • Powered gantry movement inhibited when compression is applied.
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14
Q

Why is the AEC so important in mammography? When is the AEC not used?

A
  • Due to the large variability in breast composition and thickness, determination of the exposure factors required is very difficult.
  • AEC is not used for implants due to the differences in attenuation properties when compared to breast tissue.
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15
Q

Where is the AEC located on a mammography unit? How does it work?

A
  • The AEC is integrated into the detector.
  • Certain areas of the detector are used to monitor air kerma and terminate the exposure when a limit has been reached. These areas can either be of fixed location or can be determined by the system depending on the breast being imaged.
  • For basic AECs, the operator selects kV, target and filter and the AEC selects mAs.
  • Operator selection of target and filter and AEC selection of kV and mAs is also possible on some systems. kV is selected based on compressed breast thickness or determined from measured dose rate during a low dose test shot.
  • Fully automatic AEC systems (most common) control selection of kV, mAs, target and filter based on a test shot or on the compressed breast thickness.
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16
Q

How does modern digital mammography differ from conventional screen-film mammography?

A

The target/filter combinations used in modern digital mammography generally produce a harder spectrum. This is associated with a reduction in contrast. However, in digital systems, an increase in detector dose can compensate for this without exceeding the useful dynamic range of the detector. This makes for a lower patient dose while maintaining image quality.

17
Q

How does a photon counting scanning-slot mammography system work? How does it aid in noise reduction?

A
  • Imaging is carried out by scanning a series of fine beams across the breast. The collimator and detector also scan across the breast and an image is built up.
  • Only a small volume of tissue is irradiated at any one time and, therefore, scatter is minimal (no anti-scatter grid is required).
  • The detector is a photon counting systems (i.e. a pulse is produced in detector material for each photon detected).
  • As the size of the pulse is greater than any inherent detector noise, thresholding can be applied to remove the noise.
18
Q

Why is entrance surface dose not an appropriate dosimetric quantity for mammography? What quantity is used instead and how is this calculated? How is it estimated at QA?

A
  • Due to the low energies used in mammography, there are significant variations of dose with depth. This means entrance surface dose is not appropriate.
  • Mean glandular dose is used instead. This is derived from entrance air kerma measurements using conversion factors which depend on beam quality/quantity, breast thickness and breast composition.
  • PMMA blocks are used to estimate mean glandular dose values at QA.
19
Q

Why is there a wide range of mean glandular doses for women of equivalent compressed breast thickness?

A

Breasts of a given thickness will have a wide range of compositions (from adipose to glandular).

20
Q

What is the NDRL for breast mammography?

A

Mean glandular dose for breasts 50-60 mm thick < 2.5 mGy.

21
Q

What is stereotactic mammography used for and how does it work?

A
  • Used for positioning guide wires and carrying out breast biopsies.
  • They are typically add-ons for standard mammography units.
  • Two mammographic acquisitions are performed at different, known gantry angles.
  • A marker at a known location (small dot on the breast table) is used as a reference point in both images.
  • Locations of the reference point and of the target point in each image are input into the system for localisation of the targets coordinates.
  • These coordinates can then be sent to the biopsy unit for accurate needle positioning without penetrating though the breast and striking the table.
22
Q

What advantages does breast tomosynthesis offer? How does it work?

A
  • Projection imaging like mammography suffers from superimposition of structures which can mimic or mask pathology. Compression can reduce but not eliminate these effects. Tomosynthesis can reduce these effects further by acquiring multiple projections at different gantry angles (akin to CT).
  • The x-ray tube rotates in an arc around the breast about a pivot point acquiring a series of low dose projection images. The breast and detector remain stationary.
  • Resultant images are reconstructed into slices at different depths within the breast.
23
Q

What are the disadvantages of breast tomosynthesis?

A
  • Very large datasets can cause issues when transferring data via PACS etc.
  • z-axis (depth) resolution is relatively poor due to the limited angle of acquisition.
  • Increased reporting time due to the larger number of images involved.
  • Training required in image interpretation.
24
Q

What is contrast mammography used for and how does it work?

A
  • Contrast mammography utilises iodine contrast injections to visualise areas of vascularisation within the breast that can be associated with certain types of tumours.
  • Contrast agent is injected and after sufficient uptake time, separate high and low energy acquisitions are then taken using a single compression.
  • The energy used for the high energy acquisition resides above the iodine K-edge and, therefore, results in preferential attenuation where iodine is present.
  • Low low energy acquisition is similar to a normal mammogram.
  • Subsequent image processing highlights areas of iodine uptake and supresses background.
25
Q

How is the IR(ME)R referral, justification and authorisation process different for breast screening?

A
  • There is no individual signed referral request. Instead, women are invited for screening if they meet the referral criteria.
  • The eligibility of the patient should be checked prior to authorisation.
  • Previous screening history should be considered for justification/authorisation.
26
Q

What further assessment may be required after an abnormal screening mammogram?

A
  • Further mammography including magnification views.
  • Clinical exam.
  • Ultrasound.
  • Biopsy.