Malignant primary bone tumours Flashcards

1
Q

Signs shown by malignant bone tumours on Xray

A

Cortical destruction
A periosteal reaction (raised periosteum producing bone)
New bone formation (sclerosis as well as lysis from destruction)
Extension into the surrounding soft tissue envelope

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2
Q

Most common primary bone tumour

A

Osteosarcoma

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3
Q

Describe an osteosarcoma

A

A malignant bone producing tumour.

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4
Q

Who is likely to get an osteosarcoma?

A

Adolescents- younger age groups

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5
Q

Sites where osteosarcomas affect?

A

Proximal femur
Proximal humerus
Pelvis

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6
Q

How do osteosarcomas spread?

A

Metastatic spread is usually haematoginous but can be lymphatic.

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7
Q

Treatment of osteosarcomas

A

Not radiosensitive but adjuvant chemotherapy can prolong survival.

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8
Q

Describe a chondrosacroma

A

Cartilage producing bone tumour. Less common and less aggressive than an osteosarcoma. They can be very large and slow to metastasise.

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9
Q

Which age group to chondrosarcomas affect?

A

Tends to be an older age group.

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10
Q

Where do chondrosarcomas tend to be found?

A

Pelvis or proximal femur.

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11
Q

Prognosis of chondrosarcoma

A

Dependent upon histological grade.

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12
Q

Treatment of chondrosarcoma

A

Not radiosensitive and do not respond to adjuvant chemotherapy.

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13
Q

Fibrosarcoma and Malignant Fibrous Histiocytoma

A

Fibrous malignant bone tumours that tend to occur in abnormal bone. They tend to affect adolescents or young adults.

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14
Q

Describe Ewings Sarcoma?

A

Malignant tumour of primitive cells in the marrow. 2nd most prevalent primary bone tumour and has the poorest prognosis.

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15
Q

What age group does Ewings sarcoma occur in?

A

Usually between 10 and 20.

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16
Q

Signs of Ewings sarcoma?

A

Raised inflammatory markers, fever and warm swelling. May be misdiagnosed as osteomyelitis.

17
Q

Treatment of primary bone tumours in general

A

Surgery to remove the tumour and surrounding tissue.

18
Q

Staging investigations into primary bone tumours.

A

Bone scan
CT chest
MRI
They determine the extent of the tumour and the involvement of muscle, nerves and tissues.
Biopsy is required for histological diagnosis.

19
Q

Lymphomas

A

Cancer of the lymphatic system. Can occur as a primary bone tumour (non-Hogdkins lymphoma). Tends to affect the pelvis and femur. Surgical resection is the treatment.

20
Q

Myeloma

A

Malignant B cell proliferation.