Autoimmunity and autoantibodies Flashcards
What is autoimmunity?
The immune system becomes dysfunctional and creates antibodies that attack the bodies own proteins.
Why are they seropositive?
The auto-antibodies can be found circulating in the serum of the blood.
How does autoimmunity occur?
The immune systems normal regulatory process fails and means they stop recognising proteins as there own. The immune system therefore starts producing antibodies against these (autoantibodies).
What causes autoimmunity?
Genetic predisposition plus environmental factors such as chemical exposure and infection.
Which disease/diseases is Anti-nuclear antibody associated with?
SLE, sjogrens, systemic sclerosis, MCTD and autoimmune liver disease.
Which disease/diseases is anti-Ro antibody associated with?
SLE, sjogrens disease
Which disease/diseases are anti-CCP antibody associated with?
Rheumatic arthritis
Which disease/diseases are anti-double stranded DNA associated with? (dsDNA)
SLE
Which disease/diseases are Anti-sm associated with?
SLE
Which disease/diseases are Anti-La antibodies associated with?
Sjogrens syndrome
Which disease/diseases is anti-centromere antibody associated with?
Systemic sclerosis (limited)
Which disease/diseases are anti Scl 70 antibody associated with?
Systemic sclerosis (diffuse)
Which disease/diseases are associated with anti-RNP antibody?
SLE, mixed connective tissue disease
Which disease/diseases are Anti-Jo-1 antibodies associated with?
Myositis
Which disease/diseases are anti-cardiolipin antibody and lupus anti-coagulant associated with?
Antiphospholipid syndrome
