Malignant Melanoma

Question 1

in which populations is pemphigus vulgaris more common

Answer 1

Ashkenazi jews or people from the indian sub continent

Question 2

in pemphigus vulgaris antibodies are formed against which proteins

Answer 2

desmoglein 1&3 –> superficial intra-epidermal split

Question 3

in bullous pemphigoid autoantibodies are produced against what?

Answer 3

hemidesmosomal protein –> subepidermal split through basement membrane

Question 4

which other condition is dermatitis herpetiformis associated with

Answer 4

coeliacs disease

Question 5

name as many of the emergency dermatology disease as you can

Answer 5

erythroderma
urticaria/angioedema (anaphylaxis)
toxic epidermal necrolysis
stevens johnson syndrome
purpuric rashes
cellulitis
venous leg ulcers
bullous disorders

Question 6

what should you never use on skin (think creams)

Answer 6

Aqueous BP - its bad!!

Question 7

name a weak topical steroid prep

Answer 7

hydrocortisone

Question 8

name a moderately potent topical steroid prep

Answer 8

clobetasol butyrate

Question 9

name a potent topicl steroid prep

Answer 9

betamethason valerate

Question 10

name a v potent topical steroid prep

Answer 10

clobetason proprionate

Question 11

what are gottron’s papules

Answer 11

seen in dermatomyositis
scaly erythematous papillose on extensor surfaces of hands
associated with a heliotrope rash on the face

Question 12

list disorders which might cause erythema nodosum

Answer 12

sarcoidosis
lyphoma
drugs (OCP/penecillins)
Mycoplasma pneumoniae
Strep throat

Question 13

list some causes of bilateral hillier lymphadenopathy

Answer 13

sarcoid
TB
lymphoma
multiple fungal lesions
Berylliosis

Question 14

bilateral hilar lymphadenopathy, erythema nudism with arthralgia, mild fever and uveitis is also known as

Answer 14

Lofgren syndrome

Question 15

which investigation should be carried out before compression bandaging

Answer 15

ankle-brachial pressure index

Question 16

what is guttate psoriasis

Answer 16

widespread pink merciless that look like drops of paint.

Usually follow acute beta-haemolytic streptococcal infection (throat infection)

Question 17

which HLA association do psoariatic arthropathy and Reiter’s syndrome share

Answer 17

HLA B27

Question 18

what is Reiter’s syndrome

Answer 18

reactive arthritis
tends to follow GU or GI infections
common agents: Salmonella, shigella, campylobacter chlamydia

Question 19

which two markers, which cause the release of prostaglandins and leukotrienes, are raised in psoriatic lesions

Answer 19

Phospholipase A2

Calmodulin

Question 20

list three types of drugs which might cause psoriasis

Answer 20

beta-blockers
lithium
anti-malarial drugs

Question 21

what is Koebner’s phenomenon?

Answer 21

where lesions occur in areas of trauma e.g. in psoriasis or lichen planus

Question 22

what is pityriasis versicolour and what causes it

Answer 22

flat, partially depigmented areas of skin with no inflammation or vesicles
tend to occur on tanned skin after sun exposure
caused by the yeast Pityrosporum orbiculare

Question 23

erythasma is caused by which organism

Answer 23

Corynebacterium minutissimum