Malignant Melanoma Flashcards
in which populations is pemphigus vulgaris more common
Ashkenazi jews or people from the indian sub continent
in pemphigus vulgaris antibodies are formed against which proteins
desmoglein 1&3 –> superficial intra-epidermal split
in bullous pemphigoid autoantibodies are produced against what?
hemidesmosomal protein –> subepidermal split through basement membrane
which other condition is dermatitis herpetiformis associated with
coeliacs disease
name as many of the emergency dermatology disease as you can
erythroderma urticaria/angioedema (anaphylaxis) toxic epidermal necrolysis stevens johnson syndrome purpuric rashes cellulitis venous leg ulcers bullous disorders
what should you never use on skin (think creams)
Aqueous BP - its bad!!
name a weak topical steroid prep
hydrocortisone
name a moderately potent topical steroid prep
clobetasol butyrate
name a potent topicl steroid prep
betamethason valerate
name a v potent topical steroid prep
clobetason proprionate
what are gottron’s papules
seen in dermatomyositis
scaly erythematous papillose on extensor surfaces of hands
associated with a heliotrope rash on the face
list disorders which might cause erythema nodosum
sarcoidosis lyphoma drugs (OCP/penecillins) Mycoplasma pneumoniae Strep throat
list some causes of bilateral hillier lymphadenopathy
sarcoid TB lymphoma multiple fungal lesions Berylliosis
bilateral hilar lymphadenopathy, erythema nudism with arthralgia, mild fever and uveitis is also known as
Lofgren syndrome
which investigation should be carried out before compression bandaging
ankle-brachial pressure index
what is guttate psoriasis
widespread pink merciless that look like drops of paint.
Usually follow acute beta-haemolytic streptococcal infection (throat infection)
which HLA association do psoariatic arthropathy and Reiter’s syndrome share
HLA B27
what is Reiter’s syndrome
reactive arthritis
tends to follow GU or GI infections
common agents: Salmonella, shigella, campylobacter chlamydia
which two markers, which cause the release of prostaglandins and leukotrienes, are raised in psoriatic lesions
Phospholipase A2
Calmodulin
list three types of drugs which might cause psoriasis
beta-blockers
lithium
anti-malarial drugs
what is Koebner’s phenomenon?
where lesions occur in areas of trauma e.g. in psoriasis or lichen planus
what is pityriasis versicolour and what causes it
flat, partially depigmented areas of skin with no inflammation or vesicles
tend to occur on tanned skin after sun exposure
caused by the yeast Pityrosporum orbiculare
erythasma is caused by which organism
Corynebacterium minutissimum
