Malignant Hyperthermia Flashcards
1
Q
what is malignant hyperthermia characterised by?
A
- following administration of anaesthetic agent
- hyperpyrexia
- muscle rigidity
2
Q
what is the mechanism behind malignant hyperthermia?
A
- excessive release of Ca2+ from the sarcoplasmic reticulum of skeletal muscle
- associated with defects in a gene on chromosome 19
- autosomal dominant
3
Q
what are the causative agents in malignany hyperthermia?
A
- halothane
- suxamethonium
- antipsychotics
4
Q
what investigations can be undertaken in malignant hyperthermia?
A
- CK raised
- contracture tests with halothane and caffeine
5
Q
what is the management of malignant hyperthermia?
A
dantrolene
prevents Ca2+ release form the sarcoplasmic reticulum
