Anaesthetic Agents Flashcards
what is the mechanism of action of propofol?
- GABA receptor agonists
- rapidly metabolised with little accumulation of metabolites
what does propofol do?
- rapid onset of anaesthesia
- proven anti-emetic properties
what are some of the side-effects of propofol?
- pain on IV injection
- moderate myocardial depression
what is propofol used for?
- maintaining sedation on ITU
- total IV anaesthesia
- daycase surgery
when is sodium thiopentone used?
extremely rapid onset of action making it the agent of choice for rapid sequence of induction
what are the down-sides of sodium thiopentone?
- marked myocardial depression
- metabolites build up quickly
- unsuitable for maintenance infusion
- little analgesic effects
what is the mechanism of action of ketamine?
NMDA receptor antagonist
when is ketamine used?
produces little myocardial depression making it the suitable agent for anaesthesia in those who are haemodynamically unstable
what does ketamine do?
- used for induction of anaesthesia
- moderate to strong analgesia properties
what are the side-effects of ketamine?
may induce a state of dissociative anaesthesia resulting in nightmares
when is etomidate used?
has favorable cardiac safety profile with very little haemodynamic instability
what are the down-sides of etomidate?
- no analgesic properties
- unsuitable for maintaining sedation as prolonged use may result in adrenal suppression
- post-operative vomiting is common
