Malignancy

Question 1

Allogenic bone marrow

Answer 1

Donor

Question 2

Autologous bone marrow

Answer 2

OWN

Question 3

Reed Sternberg Cells

Answer 3

Hodgkin’s Lymphoma

Question 4

Causes Hodgkin’s Lymphoma

Answer 4

malignant cells from B lymphoctyes

Question 5

Painless, lympadenopathy, fever, night sweats, weight loss

Answer 5

Hodgkin’s Dx

Question 6

Arises in a single lymph node, spreads in an orderly fashion

Answer 6

Hodgkin’s Dx

Question 7

Dx for Hodgkin’s Lymphoma

Answer 7

lymph node excisional biopsy

Question 8

Stage I Hodgkin lymphoma

Answer 8

1 lymph node region involved

Question 9

Stage II Hodgkin lymphoma

Answer 9

2 or more lymph node regions involved, on one side of the diaphragm

Question 10

Stage III Hodgkin lymphoma

Answer 10

Lymph node regions involved on both sides of the diaphragm

Question 11

Stage IV Hodgkin lymphoma

Answer 11

Disseminated disease w/ extranodal involvement

Question 12

“A” Hodgkin

Answer 12

no constitutional symptoms

Question 13

“B” Hodgkin

Answer 13

fever, night sweats, weight loss

Question 14

“X” Hodgkin

Answer 14

bulky disease; Mediastinal involvement

Question 15

Dx for Non-Hodgkin lymphoma

Answer 15

tissue biopsy

Question 16

Malignant proliferation of plasma cells originating in the bone marrow

Answer 16

Multiple Myeloma (Plasma Cell Myeloma)

Question 17

Excess of what immungobulin in multiple myeloma?

Answer 17

IgG; Monoclonal gammopathy

Question 18

Rouleaux Formation

Answer 18

Multiple myeloma

Question 19

Bence jones protein

Answer 19

Multiple myeloma

Question 20

Hypercalcemia

Answer 20

Multiple myeloma

Question 21

Monoclonal protein (M-protein) on SPEP and/or UPEP

Answer 21

Multiple Myeloma

Question 22

Lytic lesions

Answer 22

Multiple Myeloma

Question 23

Asymptomatic pt w/ hypercalcemia, increase serum protein and anemia

Answer 23

Multiple myeloma

Question 24

Txt for multiple myeloma

Answer 24

biologic agents (Lenalidomide, Bortezomib) and Dexamethasone

Question 25

Most common childhood malignancy

Answer 25

Acute lymphoblastic leukemia

Question 26

Philadephia Chromosome

Answer 26

Acute lymphoblastic leukemia

Question 27

What are lymphoblasts in "ALL" described as?

Answer 27

TdT postiive | Negative for peroxidase and Sudan black histochemical stains

Question 28

Auer rods

Answer 28

Acute Myeloid Leukemia

Question 29

How do myeloblasts look in AML?

Answer 29

positive for peroxidase and sudan black histochemical stains

Question 30

Most common form of leukemia in adults in the US

Answer 30

Chronic lymphocytic leukemia (CLL)

Question 31

Proliferation of mature appearing lymphocytes in peripheral blood that invade bone marrow, spleen, and lymph nodes

Answer 31

chronic lymphoctyic leukemia

Question 32

Hallmark is Lymphocytosis

Answer 32

Chronic Lymphocytic Leukemia (CLL)

Question 33

Smudge cells present

Answer 33

Chronic lymphocytic leukemia

Question 34

Elevated WBC >150,000

Answer 34

CML

Question 35

Hallmark bcr/abl gene is detected by PCR test in peripheral blood or bone marrow biospy

Answer 35

Chronic Myeloid Leukemia

Question 36

Txt of choice for CML?

Answer 36

Imatnib mesylate (tyrosine kinase inhibitor)