malignancy

Question 1

what malignancy is often associated with Down syndrome

Answer 1

ALL

Question 2

what chromosome is associated with ALL in 30% of adults and 3-5% of children with ALL

Answer 2

Philidelphia

Question 3

Auer rods can be seen in

Answer 3

AML

Question 4

what can allow better assessment of cellularity

Answer 4

Trephine

Question 5

chromosome 9 and 22 translocation is characteristic of Philadelphia chromosome

Answer 5

CML

Question 6

smear or smudge cells can be seen in

Answer 6

CLL

Question 7

what can CLL transform into

Answer 7

high grade lymphoma

Question 8

what lymphoma is more common

Answer 8

NHL

Question 9

burkitt lymphoma is associated with

Answer 9

epstein barr, malaria and HIV

Question 10

MALT lymphoma are associated with what infection

Answer 10

h.pylori

Question 11

how do diffuse large B cell lymphomas often present

Answer 11

rapidly growing painless mass in those over 65

Question 12

how do lymphomas lymphadenopathy tend to present

Answer 12

non tender and feel rubbery

Question 13

itch without rash can be a symptom in

Answer 13

lymphoma

Question 14

what is the key diagnostic test in lymphoma

Answer 14

lymph node biopsy

Question 15

what is the key finding from lymph node biopsy in its with Hodgkins lymphoma

Answer 15

reed Sternberg cell

Question 16

what does the reed Sternberg cell look like

Answer 16

abnormally large B cells that have multiple nuclei that have nucleoli inside them

Question 17

Ann Arbor staging used for what

Answer 17

HL

Question 18

HL management

Answer 18

ABVD - adriamycin, bleomycin, vinblastine, dacarbazine

Question 19

nHL lymphoma mx

Answer 19

R-CHOP - rituximab,cyclophosphamide,hydroxydaunorubicin (doxorubicin), vincristine (Oncovin®) andprednisolone

Question 20

what treatment in Hodgkins lymphoma can cause pneumonitis

Answer 20

bleomycin

Question 21

most patients with polycythaemia vera have what mutation

Answer 21

JAK2

Question 22

mx for polycythaemia vera

Answer 22

venesection to haematocrit below 0.45, aspirin, hydroxycarbamide

Question 23

essential thrombocythaemia defined as

Answer 23

ucontrolled production of abnormal platelets

Question 24

mx for essential thrombocythaemia

Answer 24

aspirin

Question 25

tear drop shaped RBCs

Answer 25

idiopathic myelofibrosis

Question 26

MGUS has paraprotein below what and bone marrow plasma cells below what

Answer 26

30g and then 10%

Question 27

what has the characteristic IgM paraprotein

Answer 27

waldenstroms macroglobulinaemia

Question 28

what is a clonal disorder of cells intermediate between a lymphocyte and a plasma cell

Answer 28

waldenstroms macroglobulinaemia

Question 29

what are the 2 most frequently used option in the UK for waldenstroms macroglobunimeia

Answer 29

Bendamustine-Rituximab (BR) or Dex/Cyclo/Ritux (DCR

Question 30

bence jones protein is part of the antibody called the

Answer 30

light chain

Question 31

myeloma bone disease causes what lesions

Answer 31

lytic

Question 32

immunofixation is a diagnostic test to determine the

Answer 32

paraprotein

Question 33

first line for myeloma

Answer 33

Thalidomide in combination with an alkylating agent (e.g. melphalan) and a corticosteroid (e.g. dexamethasone) is first line

Question 34

what can monitor treatment response to multiple myeloma

Answer 34

paraprotein