Male reproductive tract diseases Flashcards
How do you detect prostate enlargement?
PR exam
Prostate Specific Antigen
What does PSA do normally?
Liquifies semen in ejaculate and allows sperm to swim
What is a flaw of using PSA to detect cancer?
High grade cancers don’t produce it
What are some things that can cause an increase in PSA?
Big prostate Prostatitis PR exam Exercise Spironolactone
What investigation is used detect prostate cancer?
Biopsy (go through rectum)
What grading system is used for prostate cancer?
Gleason Grading System
What is the highest possible score on Gleason Grading System?
10
What two zones of the prostate can be affected with pathology?
Peripheral
Central
What affects the central zone of the prostate?
BPH
What affects the peripheral zone of the prostate?
Cancer
What are some symptoms of prostate cancer?
Asymptomatic
LUTS
Hematuria / Hematospermia
Bone pain, Anorexia, Weight loss
How do you diagnose prostate cancer?
PSA
Biopsy
What is the most common form of prostate cancer?
Multifocal adenocarcinoma
Where can prostate Multifocal adenocarcinoma met to?
Bones
Pelvic lymph nodes
How do you image for prostate cancer?
Bone scan
MRI
CT
How do you treat prostate cancer?
Radiotherapy Resection Treat mets w/: Androgen Deprivation therapy Diethylstilbesterol/ Steroids Cytotoxic chemotherapy
What main kind of conditions affect the penis?
Skin conditions
What causes papilloma/genital warts?
HPV
How does Balanitis Xerotic Obliterans/Lichen Sclerosus present?
White patches on penis
What causes Balanitis Xerotic Obliterans/Lichen Sclerosus?
Idiopthic
What are some complications of Balanitis Xerotic Obliterans/Lichen Sclerosus?
Cancer
Paraphimosis
Phimosis
What two forms of cancer can you get on the penis?
Differentiated- Non-HPV
Dedifferentiated- HPV
What causes differentiated penile cancer?
Non-HPV causes
What causes dedifferentiated penile cancer?
HPV
What is Paraphimosis?
Inability to replace retracted foreskin
What can cause Paraphimosis?
Having foreskin retracted for too long
What is Priapism?
Prolonged erection (> 4hrs), often painful and not associated with sexual arousal
What can cause Priapism?
Intracorporeal injection for ED, e.g. papaverine Trauma (penile / perineal) Haematologic dyscrasias e.g. sickle cell Neurological conditions Idiopathic
What are the four categories of condition that can affect the testes?
Torsion
Lumps
Orchitis
Epididymitis
What two forms of torsion are there?
Testicular
Appendage
What causes testicular torsion?
Bell Clapper Deformity
What group is testicular torsion most common in?
Teens
What are some symptoms of testicular torsion?
Excruciating pain N+V Referred pain to lower abdo testis high in scrotum transverse lie Absence of cremasteric reflex
How do you treat testicular torsion?
Surgery ASAP!!!
What are the symptoms of appendicular torsion?
Variable
Blue dot sign
How do you treat appendicular torsion?
Resolves by itself
What are the symptoms of Epididymitis?
Similar to torsion
Hx of UTI, urethritis, catheterization/instrumentation
How do you treat epididymitis?
Analgesia + scrotal support
Bed rest
Ofloxacin 400mg/day for 14 days
What can cause lumps in the testes/scrotum?
Hernia- common
Tumours
Cystocoele
Hydrocoele
What is cystocoele?
Cystic change within the vas of the epididymis
What are the symptoms of cystocoele?
Asymptomatic
What is hydrocoele?
Accumulation of fluid around the testes
What are the symptoms of hydrocoele?
Unicystic
Smooth
Fluid filled
What two broad categories of tumour can affect the testes?
Seminomatous
Non-seminomatous
In what age group are seminomatous tumours usually found?
40+
What do seminomatous tumours look like?
Potato
What is a risk factor for seminomatous tumours?
Undescended testes
How do you treat seminomatous tumours?
Radiotherapy
At what age do non-seminomatous tumours tend to present?
30ish
Describe non-seminomatous tumours
Aggressive
Metastatic
How do you treat non-seminomatous tumours?
Chemo
What is Fournier’s gangrene?
Necrotizing fasciitis in the male genitals
What are some risk factors for Fournier’s gangrene?
Diabetes
Trauma
Periurethral extravasation
Infection
What are some symptoms of Fournier’s gangrene?
Starts as cellulitis swollen erythematous tender Marked pain, fever, systemic toxicity Swelling + crepitus of scrotum, dark purple areas
What are the two categories of priapism?
Ischemic
Non-ischemic
Describe ischemic priapism
Compartment syndrome of the penis. Penis often painful.
Describe non-ischemic priapism
Traumatic disruption of penile vasculature results in unregulated blood entry and filling of corpora.
How do you treat priapism?
Aspirate blood from penis
Give alpha agonists