Male reproductive system Flashcards
The Y chromosome contains which gene that codes for the production of Testis-Determining Factor (TDF)?
SRY (Sex-Determining Region of the Y)
permits differentiation into male sex organs
lack of gene permits differentiation into female sex organs
What happens in male (XY) gender differentiation?
testes develop
testosterone from Leydig cells
Wolffian ducts develop into male genitalia
Müllerian inhibiting factor from Leydig cells
Müllerian ducts degenerate
What are the male reproductive organs?
gonads - testes
internal genitalia - epididymis, vas deferens, accessory glands (seminal vesicles, prostate gland, bulbourethral glands)
external genitalia - scrotum, penis
During the third to fifth months, the cells in the testes differentiate into which three main types of cell?
spermatogonia, Leydig cells, Sertoli cells
What are spermatogonia?
germ cells for sperm formation
What are Leydig cells?
outside seminiferous tubules
produce testosterone which develops male reproductive system by differentiation of Wolffian ducts and common primordial genital tissue
What are Sertoli cells?
produce anti-Müllerian hormone
immature Sertoli cells secrete testosterone and Müllerian-Inhibiting Factor (MIF) to inhibit differentiation of Müllerian ducts into female reproductive system
act as ‘nurse’ cells for germ cells (foetal spermatogonia)
When does the male external genitalia develop?
third and fourth months of gestation
When do the testes begin to descend through the inguinal canal?
6-10 weeks
When do the testes enter the scrotum?
around 28 weeks
What are the functions of the male reproductive system?
testes - to produce the male gametes (sperm) and male hormones (testosterone)
spermatic ducts and accessory glands - to carry sperm through the tubules for activation
penis - to penetrate the female and deposit sperm within the female reproductive system
What are the testes?
reproductive glands which produce sperm
oval in shape
4-5 cm long and 2.5 cm in diameter
produced in abdomen and descend into scrotum
suspended in scrotum by spermatic cord
scrotum hangs outside the body to maintain testes at a temperature 1-2°C lower than core body temperature (optimal temperature for sperm production) and to ensure they are not exposed to intra-abdominal pressure causing sperm to be squeezed out of the testes before maturation
testicular artery, vein and nerve supply enter testes via spermatic cord
What is cryptorchidism?
failure of testes to descend into scrotum
results in infertility if uncorrected
What are the three layers of tissue within the testis?
tunica vaginalis, tunica albuginea, tunica vasculosa
What is the tunica vaginalis?
covers anterior and lateral surfaces of testis
derived from peritoneum with descent of testis
fluid in cavity prevents friction within scrotum
What is the tunica albuginea?
fibrous tissue
covers and creates partitions between seminiferous tubules
connected to the tunica vaginalis and epididymis
What is the tunica vasculosa?
innermost layer of connective tissue
contains blood supply to testis
How many lobules does each testis contain?
200-300
How many seminiferous tubules does each lobule contain?
1-4
Sperm are composed of which three sections?
head, mid-piece, tail (flagellum)
What is the structure and function of the head?
nucleus contains 23 chromosomes
acrosome contains enzymes to penetrate ovum for fertilisation
What is the structure and function of the mid-piece?
contains mitochondria for energy
What is the function of the tail (flagellum)?
to propel sperm through female reproductive tract
How do Sertoli cells support maturation?
provide nutrients to germ cells
remove waste material from germ cells
How are Sertoli cells activated?
by FSH and testosterone
Sertoli cells produce which peptide hormone?
inhibin
What is the function of inhibin?
to inhibit FSH production
to increase spermatogenesis