Malaria

Question 1

Antimalarial drugs (9 drugs)

Answer 1

Quinine
Chloroquine
Mefloquinine 
Primaquine
Artesunate
Artemether 
Proguanil
Pyrimethamine
Sulfadoxine

Question 2

First line for severe falciparum malaria

Answer 2

Artesunate

Question 3

Antimalarial drug with the most rapid action (2 drugs)

Answer 3

Artesunate

Artemether

Question 4

Artesunate & artemether - MOA

Answer 4

Form carbon-based free radicals that alkylate heme and proteins in malarial parasites.

Question 5

Antimalarial drug also used for jiroveci infections

Answer 5

Atovaquone

Question 6

Drug used for toxoplasmosis and malaria

Answer 6

Pyrimethamine

Question 7

Which antimalarial drugs have synergistic activity?

Answer 7

Pyrimethamine & Sulfadoxine

Question 8

Pyrimethamine & sulfadoxine - adverse effects

Answer 8

Megaloblastic anemia

Steven-Johnson syndrome

Question 9

Which antimalarial drug should not be prescribed during pregnancy?

Answer 9

Chloroquine

Question 10

Chloroquine - adverse effects

Answer 10

Retinal damage & blindness

Exacerbation of psoriasis

Question 11

Which drug is associated with neuropsychiatric syndrome?

Answer 11

Mefloquine

Question 12

The only antimalrial drug that is active for the hepatic stage of malaria

Answer 12

Primaquine

Question 13

Primaquine must be included in the treatment of which types of malaria?

Answer 13

P. vivax

P. ovale

Question 14

Primaquine - adverse effect

Answer 14

In G6PD deficiency: hemolytic anemia

Question 15

Primaquine - MOA

Answer 15

Form quinolones that oxidize and destroy schizont membranes

Question 16

Antimalarial drugs that inhibits folate (and inhibited enzymes)

Answer 16

Proguanil - folate reductase
Pyrimethamine - dihydrofolate reductase
Sulfadoxine - inh synthesis of dihydrofolate