Anthelmintic drugs

Question 1

Drugs for nematode infections (5 drugs)

Answer 1

Albendazole
Mebendazole
Pyrantel
Ivermectin
Diethylcarbamazine (DEC)

Question 2

Benzimidazole drugs (2 drugs)

Answer 2

Albendazole

Mebendazole

Question 3

Benzimidazoles - MOA

Answer 3

Binds β-tubulin and inhibit its polymerization to form microtubules in the parasites. Makes it impossible for them to obtain glucose.

Question 4

Drugs against nematodes that are contraindicated in pregnancy (2 drugs)

Answer 4

Albendazole
Mebendazole
(the benzimidazoles)

Question 5

Benzimidazoles - indications

Answer 5

Intestinal nematode infections

Trichinosis

Question 6

Drug used for river blindness and scabies

Answer 6

Ivermectin

Question 7

Drug associated with severe hypersensitivity

Answer 7

Diethylcarbamazine (DEC)

Question 8

Diethylcarbamazine - indications

Answer 8

Elephantiasis

Question 9

Drugs indicated for trematode and cestode infections (5 drugs)

Answer 9

Pranziquantel
Triclabendazole
Bithionol
Oxamniquine
Niclosamide

Question 10

Drug of choice for tissue flukes and tapeworms

Answer 10

Praziquantel

Question 11

Drug of choice for sheep live fluke

Answer 11

Triclabendazole

Question 12

Praziquantel - MOA

Answer 12

Increase calcium permeability of the tegument, and cause depolarization. This exposes antigens, and cause host immune reaction

Question 13

Drug that cross brain blood-barrier

Answer 13

Praziquantel