Lumen and tissue-dwelling protozoa

Question 1

Drugs against lumen and tissue-dwelling protozoa (2 groups)

Answer 1

Nitromidazoles

Luminal amebicides

Question 2

Nitromidazoles (2 drugs)

Answer 2

Metronidazole

Tinidazole

Question 3

2nd generation nitromidazole (1 drug)

Answer 3

Tinidazole

Question 4

Drug of choice for amebiasis, giardiasis, trichomoniasis and enterocolitis by C. difficile

Answer 4

Metronidazole

Question 5

Metronidazole - MOA

Answer 5

Inhibit pyruvate-ferredoxin oxidoreductase (PFOR)

Question 6

Cautions during metronidazole treatments

Answer 6

Alcohol (disulfiram-like reaction)

Avoid in first trimester

Question 7

Drug used for rosacea

Answer 7

Metronidazole

Question 8

Adverse effects of metronidazole

Answer 8

Metallic taste

Thrombocytopenia

Question 9

Tinidazole - indications

Answer 9

Trichomoniasis, giardiasis, intestinal amebiasis, amebic liver disease, bacterial vaginosis

Question 10

Tinidazole - contraindications

Answer 10

Firs trimester of pregnancy

Question 11

Luminal amebicides (3 drugs)

Answer 11

Iodoquinol
Paramomycin
Diloxanide

Question 12

Luminal amebicides are used in combination treatment for

Answer 12

Amebic dysentery

Liver abscess

Question 13

Drug indicated for cryptosproidiosis and ascariasis

Answer 13

Nitazoxanide