Malabsorption Flashcards
1
Q
What is coeliac disease?
A
autoimmune disease caused by the exposure to gluten and it’s breakdown products
2
Q
What are the GI manifestations of coeliac disease?
A
- chronic + recurring diarrhoea
- steatorrhea
- bloating
- flatulence
- pain
3
Q
How does coeliac disease manifest in children?
A
- failure to thrive
- puberty delay
4
Q
Skin, neuro and other autoimmune manifestations of coeliac disease?
A
- dermatitis herpatiformis
- peripheral neuropathy
- T1DM
5
Q
What anti-bodies do you look for in coeliac disease?
A
- Anti-tissue transglutaminase
- anti-endomysial antibody
- anti-deamidated gliandin antibody
6
Q
What other important investigation should you perform in suspected coeliac disease cases?
A
- endoscopy with biopsy of the small bowel
- findings - cyrpt hyperplasia and villous atrophy
7
Q
What are 3 causes of pancreatic insufficiency?
A
- CF
- chronic pancreatitis
- pancreatic obstruction (Ca)
8
Q
What findings in a stool sample would make you think of pancreatic insufficiency?
A
low elastase
9
Q
what is the treatment for pancreatic insufficiency?
A
PERT
pancreatic enzyme replacement therapy
