Making a medicine

Question 1

what is a drug?

Answer 1

the active ingredient or therapeutic agent

Question 2

what is a medicine?

Answer 2

delivery system for a drug

Question 3

what is a dosage form?

Answer 3

physical form of medicine

Question 4

what is an excipient?

Answer 4

added ingredient that is not the drug

Question 5

Lipinski’s rule of 5 for oral drugs?

Answer 5

1) weight less than 500
2) logP less than 5
3) no more than 5 H bond donors
4) no more than 10 H bond acceptors

Question 6

what does Lipinski’s rule assume?

Answer 6

that there is passive diffusion

Question 7

what is logP?

Answer 7

measure of how hydrophilic or hydrophobic
determines permeabilty

Question 8

BSC class 1?

Answer 8

high solubility
high permeability

Question 9

BSC class 2?

Answer 9

low solubility
high permeability

Question 10

BSC class 3?

Answer 10

high solubility
low permeability

Question 11

BSC class 4?

Answer 11

low solubility
low permeability

Question 12

what is solubility?

Answer 12

max amount of solute that can be dissolved in a given solvent

Question 13

importance of pKa?

Answer 13

affects solubility in parts of the body