Making A Medicine Flashcards
1
Q
Drug
A
API
2
Q
Medicine
A
Drug with the excipients
3
Q
Excipient
A
Additional ingredients in the medicine
4
Q
Formulation
A
Recipe for making a medicine
5
Q
Pharmaceutics
A
The science of medicine design and manufacture
6
Q
Drug properties include…
A
Molecular weight solubility pkA log P Stability Melting point solid form particle shape
7
Q
What 3 things are determined in the pre-formulation stage?
A
The physiochemical properties of the drug are determined
- stability and compatibility
- ease of formulation
- processability
8
Q
Lipinski’s rule of 5:
A
Molecular weight < 500 Da
Log P < 5
H-bond donors < 5
H-bond acceptors < 10
9
Q
What affects solubility?
A
solvent and solute properties
temperature
pressure
10
Q
The higher the logP…
A
the more lipophilic, lower aqueous solubility
11
Q
Octanol is…
A
most commonly used organic solvent
12
Q
Log P equation:
A
log (conc of octanol/ conc of water)
13
Q
Drugs are more water soluble when…
A
ionised
