Major Drug Interactions

Question 1

Ferrous Sulfate—Feosol- Generics?
Iron Preparation

Answer 1

Antacids, bisphosphonates, tetracyclines, quinolones

Question 2

Esomeprazole- Nexium
Pantoprazole- Protonix
PPI
(Interactions)

Answer 2

CYP2C19 inducers, drugs that require acidic pH for absorption (eg. atazanavir, rilpivirine, itraconazole), clopidogrel, methotrexate

Drugs that require acidic pH for absorption (eg. atazanavir)
Clopidegral

Question 3

Adalimumab- Humira
Etanercept- Enbrel
Monoclonal Antibody/ TNF Blocking Agent

Answer 3

Anti-TNF agents, immunosuppressants, live vaccines
Live vaccines

Immunosuppressants

Question 4

Hydroxychloroquine–Plaquenil
Antimalarial, aminoquinoline

Answer 4

Cimetidine, mefloquine, remdesivir

Mefloquine

Question 5

Methotrexate–Rheumatrex
Antimetabolite (Antifolate)

Answer 5

NSAIDs, sulfonamide antibiotics, trimethoprim, vaccines, PPIs, nephrotoxic drugs, immunosuppressants

NSAIDs

Question 6

Allopurinol–Zyloprim
Xanthine Oxidase Inhibitor
(Interactions)

Answer 6

Substrates of xanthine oxidase (e.g. azathioprine, didanosine, mercaptopurine), pegloticase, vitamin k antagonists

Pegloticase

Question 7

Metoclopramide- Reglan
Antiemetic

Answer 7

CYP2D6 inhibitors, anti-parkinson drugs (dopamine agonists), antipsychotic drugs, MAOIs, linezolid

Dopamine agonists

Question 8

Ondansetron- Zofran
Antiemetic

Answer 8

CYP3A4 inducers, QTc prolonging drugs, apomorphine

CYP3A4 inducers

Question 9

Dicyclomine–Bentyl
Anticholinergic Agent

Answer 9

Potassium chloride, potassium citrate, anticholinergic drugs

Potassium citrate

Question 10

Trentinoin–Atralin, Renova, Retin-A
Retinoic acid derivative

Answer 10

Photosensitizing agents: enhanced photosensitivity

Question 11

hydrocodone/acetaminophen–Vicodin, Norco
Analgesic combination (Opioid)

Answer 11

CYP3A4 inducers/inhibitors, CNS depressants, Benzodiazepines

CNS depressants

Question 12

Dolutegravir–Tivicay
Integrase Inhibitor (INSTI)

Answer 12

Cation-containing medications (i.e. antacids, calcium/iron supplements) dofetilide, metformin

Dofetilide

Question 13

Tenofovir alafenamide
Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Answer 13

Carbamazepine, oxcarbazepine, phenobarbital, phenytoin, St. John’s Wort

Question 14

Tenofovir disoproxil fumarate (TDF)
Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Answer 14

NSAIDs

Question 15

Bictegravir
Integrase Inhibitor (INSTI)

Answer 15

Cation-containing medications (i.e. antacids, calcium/iron supplements), dofetilide, metformin

Question 16

Darunavir
Protease Inhibitor (PI)

Answer 16

CYP3A4 inhibitors. Lovastatin, simvastatin, some corticosteroids (i.e. budesonide, fluticasone, mometasone, triamcinolone), St. John’s Wort, carbamazepine, phenobarbital, phenytoin, Factor Xa inhibitors, amiodarone, dofetilide

Lovastatin

Question 17

Rilpivirine
Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Answer 17

CYP3A4 inducers. Antacids, proton pump inhibitors, St. John’s Wort carbamazepine, oxcarbazepine, phenobarbital, phenytoin

Question 18

Elvitegravir
Integrase Inhibitor (INSTI)

Answer 18

Cation-containing medications (i.e. antacids, calcium/iron supplements), dofetilide, metformin

Question 19

latanoprost -
travoprost - Travatan

Answer 19

None

Question 20

phenazopyridine

Answer 20

None

Question 21

mupirocin

Answer 21

None

Question 22

Symtuza
(Interactions)

Answer 22

Carbamazepine

Question 23

Odefsey
(Interactions)

Answer 23

Proton pump inhibitors

Question 24

Genvoya
(ADE)

Answer 24

Mometasone

Question 25

bictegravir/emtricitabine/tenofovir alafenamide
(Interactions)

Answer 25

Calcium supplements