ADE

Question 1

Loperamide- Imodium A-D
Antidiarrheal

Answer 1

Boxed warning: torsades de pointes with use of high doses;Dizziness, drowsiness, constipation, abdominal cramps, nausea

Boxed warning for torsades with high doses

Question 2

Bisacodyl- Dulcolax
Laxative stimulant

Answer 2

Mild abdominal cramps; nausea, vomiting, electrolyte disturbances
Electrolyte disturbances

Question 3

Senna- Ex-Lax, Senokot
Laxative stimulant

Answer 3

GI: Abdominal cramps, diarrhea, nausea, vomiting

Abdominal cramps

Question 4

docusate sodium–Colace
stool softener

Answer 4

Throat irritation

Question 5

Polyethylene Glycol 3350–Miralax
osmotic laxative

Answer 5

GI: bloating/abdominal distention, flatulence, diarrhea, stomach cramps, anal irritation, nausea, vomiting

Bloating

Question 6

Ferrous Sulfate—Feosol- Generics?
Iron Preparation

Answer 6

Dark stools, abdominal pain, hartburn, nausea, constipation
Dark stools, constipation

Question 7

Esomeprazole- Nexium
Pantoprazole- Protonix
PPI

Answer 7

Increase risk of C. diff infection and fractures (long term use)

Fractures (long term use)

Question 8

Adalimumab- Humira
Etanercept- Enbrel
Monoclonal Antibody/ TNF Blocking Agent

Answer 8

Headache, skin rash, injection site reactions, reactivation of latent infections (TB, Hepatitis B), heart failure BBW - serious infections, malignancies

Reactivation of latent infections
Black box warning for serious infections

Question 9

Hydroxychloroquine–Plaquenil
Antimalarial, aminoquinoline

Answer 9

Cardiovascular: QT prolongation, cardiomyopathy, conduction abnormalities (AV block, bundle branch block), pulmonary hypertension; Hemolysis (if G6PD deficiency), hypersensitivity reactions (delayed) ranging from maculopapular rash to severe skin reactions, hyperglycemia, neuromuscular (skeletal muscle myopathy), neuropsychiatric (hallucinations,psychosis, psychomotor agitation, suicidal thoughts/behavior), retinal toxicity (retinopathy), decreased visual acuity

Retinopathy

Question 10

Methotrexate–Rheumatrex
Antimetabolite (Antifolate)

Answer 10

GI: nausea, vomiting, diarrheaOther: myelosuppression, alopecia, stomatitis, photosensitivity, rash, interstitial lung disease, Stevens-Johnson syndromeBBW - bone marrow suppression, renal impairment, hepatotoxicity, pneumonitis, GI toxicity, secondary malignancy, tumor lysis syndrome, dermatologic toxicity, opportunistic infections, radiotherapy, fetal toxicity

Bone marrow suppression

Question 11

Allopurinol–Zyloprim
Xanthine Oxidase Inhibitor

Answer 11

Derm: skin rash, hypersensitivity (Stevens-Johnson, toxic epidermal necrolysis, DRESS)GI: nausea, increased LFTsOther: renal impairment, acute gout

Skin rash

Question 12

Metoclopramide- Reglan
Antiemetic

Answer 12

CNS: fatigue, muscle weakness, somnolence, dizziness, visual disturbances, extrapyramidal reactions, hallucinationsCV: arrhythmias, hypertensionOther: hyperprolactinemia, neuroleptic malignant syndrome BBW: tardive diskynesia

Extrapyramidal reactions

Question 13

Ondansetron- Zofran
Antiemetic

Answer 13

CNS: dizziness, headacheCV: arrhythmia, QTc prolongation GI: constipation, diarrhea, xerostomia Other: anaphylaxis, serotonin syndrome

QTc prolongation

Question 14

Dicyclomine–Bentyl
Anticholinergic Agent

Answer 14

CNS: dizziness, drowsiness, psychosisCV: tachycardia GI: xerostomia, constipation Other: decreased sweating, blurred vision, urinary retention

Drowsiness

Question 15

Trentinoin–Atralin, Renova, Retin-A
Retinoic acid derivative

Answer 15

Application site reactions: erythema, burning, stinging, dry skin; Photosensitivity

Dry skin

Question 16

Latanoprost- Xalatan
Trevoprost- Travatan
Prostaglandin

Answer 16

Blurred vision, itching, sensation of foreign body in eye, eye hyperpigmentation, dry eye, eyelid edema

Blurred vision
Dry eye

Question 17

hydrocodone/acetaminophen–Vicodin, Norco
Analgesic combination (Opioid)

Answer 17

CNS: dizziness, drowsinessGI: constipation
BBW: addiction, abuse, and misuse; life threatening respiratory distress; hepatotoxicity; neonatal opioid withdrawal

Constipation

Question 18

Phenzopyridine–Pyridium
Analgesic, Urinary

Answer 18

GI: stomach cramps GU: red-orange discoloration of urine

Red-orange discoloration of urine

Question 19

Mupirocin–Bactroban
Antibiotic, Topical

Answer 19

Application site pain or burning, pruritus, rash

Application site burning

Question 20

Dolutegravir–Tivicay
Integrase Inhibitor (INSTI)

Answer 20

Weight gain

Question 21

Tenofovir alafenamide
Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Answer 21

Hypercholesterolemia, weight gain. Boxed Warning - Do not abruptly discontinue therapy in patients with Hepatitis B (may cause exacerbation)

Question 22

Emtricitabine
Nucleoside reverse transcriptase inhibitor (NRTI)

Answer 22

Diarrhea, nausea, headache
Boxed Warning - Do not abruptly discontinue therapy in patients with Hepatitis B (may cause exacerbation)

Question 23

Bictegravir
Integrase Inhibitor (INSTI)

Answer 23

Weight gain

Question 24

Darunavir
Protease Inhibitor (PI)

Answer 24

Hypercholesterolemia, diarrhea, nausea, vomiting

Question 25

obicistat
Boosting agent

Answer 25

Hyperbilirubinemia, hypercholesterolemia, increased serum creatinine

Question 26

Tenofovir disoproxil fumarate (TDF)
Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Answer 26

Decreased bone mineral density, renal insufficiency (rarely AKI or Fanconi syndrome can occur)Boxed Warning - Do not abruptly discontinue therapy in patients with Hepatitis B (may cause exacerbation)

Decreased bone mineral density

Question 27

Truvada

Answer 27

Renal insufficiency

Question 28

Descovy

Answer 28

Hypercholesterolemia